Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER(+) Breast Cancer

PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these...

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Detalles Bibliográficos
Autores principales: Ros, Susana, Wright, Alan J., D'Santos, Paula, Hu, De-en, Hesketh, Richard L., Lubling, Yaniv, Georgopoulou, Dimitra, Lerda, Giulia, Couturier, Dominique-Laurent, Razavi, Pedram, Pelossof, Rapahel, Batra, Ankita S., Mannion, Elizabeth, Lewis, David Y., Martin, Alistair, Baird, Richard D., Oliveira, Mafalda, de Boo, Leonora W., Linn, Sabine C., Scaltriti, Maurizio, Rueda, Oscar M., Bruna, Alejandra, Caldas, Carlos, Brindle, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562820/
https://www.ncbi.nlm.nih.gov/pubmed/32976773
http://dx.doi.org/10.1016/j.ccell.2020.08.016

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