Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia

A case of an early‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL.

Detalles Bibliográficos
Autores principales: Zappone, Elisabetta, Cencini, Emanuele, Defina, Marzia, Sicuranza, Anna, Gozzetti, Alessandro, Ciofini, Sara, Raspadori, Donatella, Mecacci, Bianca, Bocchia, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562845/
https://www.ncbi.nlm.nih.gov/pubmed/33088538
http://dx.doi.org/10.1002/ccr3.3041
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author Zappone, Elisabetta
Cencini, Emanuele
Defina, Marzia
Sicuranza, Anna
Gozzetti, Alessandro
Ciofini, Sara
Raspadori, Donatella
Mecacci, Bianca
Bocchia, Monica
author_facet Zappone, Elisabetta
Cencini, Emanuele
Defina, Marzia
Sicuranza, Anna
Gozzetti, Alessandro
Ciofini, Sara
Raspadori, Donatella
Mecacci, Bianca
Bocchia, Monica
author_sort Zappone, Elisabetta
collection PubMed
description A case of an early‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL.
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spelling pubmed-75628452020-10-20 Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia Zappone, Elisabetta Cencini, Emanuele Defina, Marzia Sicuranza, Anna Gozzetti, Alessandro Ciofini, Sara Raspadori, Donatella Mecacci, Bianca Bocchia, Monica Clin Case Rep Case Reports A case of an early‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL. John Wiley and Sons Inc. 2020-07-07 /pmc/articles/PMC7562845/ /pubmed/33088538 http://dx.doi.org/10.1002/ccr3.3041 Text en © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Zappone, Elisabetta
Cencini, Emanuele
Defina, Marzia
Sicuranza, Anna
Gozzetti, Alessandro
Ciofini, Sara
Raspadori, Donatella
Mecacci, Bianca
Bocchia, Monica
Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title_full Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title_fullStr Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title_full_unstemmed Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title_short Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
title_sort venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early t‐cell lymphoblastic leukemia
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562845/
https://www.ncbi.nlm.nih.gov/pubmed/33088538
http://dx.doi.org/10.1002/ccr3.3041
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