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CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus

Recent studies have shown higher levels of CTRP-1 (C1QTNF-related protein) in patients with type 2 diabetes compared to controls. We aimed at investigating CTRP-1 in gestational diabetes mellitus (GDM). CTRP-1 levels were investigated in 167 women (93 with normal glucose tolerance (NGT), 74 GDM) of...

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Autores principales: Deischinger, Carola, Leitner, Karoline, Baumgartner-Parzer, Sabina, Bancher-Todesca, Dagmar, Kautzky-Willer, Alexandra, Harreiter, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562865/
https://www.ncbi.nlm.nih.gov/pubmed/33060724
http://dx.doi.org/10.1038/s41598-020-74413-1
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author Deischinger, Carola
Leitner, Karoline
Baumgartner-Parzer, Sabina
Bancher-Todesca, Dagmar
Kautzky-Willer, Alexandra
Harreiter, Jürgen
author_facet Deischinger, Carola
Leitner, Karoline
Baumgartner-Parzer, Sabina
Bancher-Todesca, Dagmar
Kautzky-Willer, Alexandra
Harreiter, Jürgen
author_sort Deischinger, Carola
collection PubMed
description Recent studies have shown higher levels of CTRP-1 (C1QTNF-related protein) in patients with type 2 diabetes compared to controls. We aimed at investigating CTRP-1 in gestational diabetes mellitus (GDM). CTRP-1 levels were investigated in 167 women (93 with normal glucose tolerance (NGT), 74 GDM) of a high-risk population for GDM. GDM was further divided into GDM subtypes depending on a predominant insulin sensitivity issue (GDM-IR) or secretion deficit (GDM-IS). Glucose tolerance was assessed with indices [Matsuda index, Stumvoll first phase index, insulin-secretion-sensitivity-index 2 (ISSI-2), area-under-the-curve (AUC) insulin, AUC glucose] derived from an oral glucose tolerance test (oGTT) performed at < 21 and 24–28 weeks of gestation. In pregnancy, CTRP-1 levels of GDM (76.86 ± 37.81 ng/ml) and NGT (82.2 ± 35.34 ng/ml; p = 0.104) were similar. However, GDM-IR women (65.18 ± 42.18 ng/ml) had significantly lower CTRP-1 levels compared to GDM-IS (85.10 ± 28.14 ng/ml; p = 0.009) and NGT (p = 0.006). CTRP-1 levels correlated negatively with weight, AUC insulin, Stumvoll first phase index, bioavailable estradiol and positively with HbA1c, Matsuda Index and ISSI-2. A multiple regression analysis revealed bioavailable estradiol (β = − 0.280, p = 0.008) and HbA1c (β = 0.238; p = 0.018) as the main variables associated with CTRP-1 in GDM. Postpartum, waist and hip measurements were predictive of CRTP-1 levels instead. CTRP-1 levels were higher postpartum than during pregnancy (91.92 ± 47.27 vs.82.44 ± 38.99 ng/ml; p = 0.013). CTRP-1 is related to insulin resistance in pregnancy and might be a metabolic biomarker for insulin resistance in GDM. CTRP-1 levels were significantly lower during pregnancy than postpartum, probably due to rising insulin resistance during pregnancy.
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spelling pubmed-75628652020-10-19 CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus Deischinger, Carola Leitner, Karoline Baumgartner-Parzer, Sabina Bancher-Todesca, Dagmar Kautzky-Willer, Alexandra Harreiter, Jürgen Sci Rep Article Recent studies have shown higher levels of CTRP-1 (C1QTNF-related protein) in patients with type 2 diabetes compared to controls. We aimed at investigating CTRP-1 in gestational diabetes mellitus (GDM). CTRP-1 levels were investigated in 167 women (93 with normal glucose tolerance (NGT), 74 GDM) of a high-risk population for GDM. GDM was further divided into GDM subtypes depending on a predominant insulin sensitivity issue (GDM-IR) or secretion deficit (GDM-IS). Glucose tolerance was assessed with indices [Matsuda index, Stumvoll first phase index, insulin-secretion-sensitivity-index 2 (ISSI-2), area-under-the-curve (AUC) insulin, AUC glucose] derived from an oral glucose tolerance test (oGTT) performed at < 21 and 24–28 weeks of gestation. In pregnancy, CTRP-1 levels of GDM (76.86 ± 37.81 ng/ml) and NGT (82.2 ± 35.34 ng/ml; p = 0.104) were similar. However, GDM-IR women (65.18 ± 42.18 ng/ml) had significantly lower CTRP-1 levels compared to GDM-IS (85.10 ± 28.14 ng/ml; p = 0.009) and NGT (p = 0.006). CTRP-1 levels correlated negatively with weight, AUC insulin, Stumvoll first phase index, bioavailable estradiol and positively with HbA1c, Matsuda Index and ISSI-2. A multiple regression analysis revealed bioavailable estradiol (β = − 0.280, p = 0.008) and HbA1c (β = 0.238; p = 0.018) as the main variables associated with CTRP-1 in GDM. Postpartum, waist and hip measurements were predictive of CRTP-1 levels instead. CTRP-1 levels were higher postpartum than during pregnancy (91.92 ± 47.27 vs.82.44 ± 38.99 ng/ml; p = 0.013). CTRP-1 is related to insulin resistance in pregnancy and might be a metabolic biomarker for insulin resistance in GDM. CTRP-1 levels were significantly lower during pregnancy than postpartum, probably due to rising insulin resistance during pregnancy. Nature Publishing Group UK 2020-10-15 /pmc/articles/PMC7562865/ /pubmed/33060724 http://dx.doi.org/10.1038/s41598-020-74413-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Deischinger, Carola
Leitner, Karoline
Baumgartner-Parzer, Sabina
Bancher-Todesca, Dagmar
Kautzky-Willer, Alexandra
Harreiter, Jürgen
CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title_full CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title_fullStr CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title_full_unstemmed CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title_short CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
title_sort ctrp-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562865/
https://www.ncbi.nlm.nih.gov/pubmed/33060724
http://dx.doi.org/10.1038/s41598-020-74413-1
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