Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutat...

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Detalles Bibliográficos
Autores principales: Sumer, Simon Alexander, Hoffmann, Sandra, Laue, Svenja, Campbell, Birgit, Raedecke, Kristin, Frajs, Viktoria, Clauss, Sebastian, Kääb, Stefan, Janssen, Johannes W.G., Jauch, Anna, Laugwitz, Karl-Ludwig, Dorn, Tatjana, Moretti, Alessandra, Rappold, Gudrun A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562944/
https://www.ncbi.nlm.nih.gov/pubmed/32976766
http://dx.doi.org/10.1016/j.stemcr.2020.08.015

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