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Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()

Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Lange...

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Autor principal: Hussein, Mahmoud Rezk Abdelwhaed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562995/
https://www.ncbi.nlm.nih.gov/pubmed/32711930
http://dx.doi.org/10.1016/j.abd.2020.04.006
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author Hussein, Mahmoud Rezk Abdelwhaed
author_facet Hussein, Mahmoud Rezk Abdelwhaed
author_sort Hussein, Mahmoud Rezk Abdelwhaed
collection PubMed
description Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development.
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spelling pubmed-75629952020-10-20 Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()() Hussein, Mahmoud Rezk Abdelwhaed An Bras Dermatol Dermatopathology Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development. Sociedade Brasileira de Dermatologia 2020 2020-07-12 /pmc/articles/PMC7562995/ /pubmed/32711930 http://dx.doi.org/10.1016/j.abd.2020.04.006 Text en © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Dermatopathology
Hussein, Mahmoud Rezk Abdelwhaed
Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title_full Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title_fullStr Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title_full_unstemmed Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title_short Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma()()
title_sort immunohistochemical analysis of s100-positive epidermal langerhans cells in dermatofibroma()()
topic Dermatopathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562995/
https://www.ncbi.nlm.nih.gov/pubmed/32711930
http://dx.doi.org/10.1016/j.abd.2020.04.006
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