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Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

OBJECTIVE: The endocannabinoid (eCB) system is increasingly recognized as being crucially important in obesity-related hepatic steatosis. By activating the hepatic cannabinoid-1 receptor (CB(1)R), eCBs modulate lipogenesis and fatty acid oxidation. However, the underlying molecular mechanisms are la...

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Detalles Bibliográficos
Autores principales:	Azar, Shahar, Udi, Shiran, Drori, Adi, Hadar, Rivka, Nemirovski, Alina, Vemuri, Kiran V., Miller, Maya, Sherill-Rofe, Dana, Arad, Yhara, Gur-Wahnon, Devorah, Li, Xiaoling, Makriyannis, Alexandros, Ben-Zvi, Danny, Tabach, Yuval, Ben-Dov, Iddo Z., Tam, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563015/ https://www.ncbi.nlm.nih.gov/pubmed/32987186 http://dx.doi.org/10.1016/j.molmet.2020.101087

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