Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials. Herein, for the first time, we reported the d...

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Detalles Bibliográficos
Autores principales: Ma, Liying, Wang, Haojie, You, Yinghua, Ma, Chaoya, Liu, Yuejiao, Yang, Feifei, Zheng, Yichao, Liu, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563019/
https://www.ncbi.nlm.nih.gov/pubmed/33088686
http://dx.doi.org/10.1016/j.apsb.2020.02.006

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