Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients

Background. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shap...

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Autores principales: Lagrange, Jeremy, Wagner, Bianca, Nagler, Markus, ten Cate, Vincent, Pallares Robles, Alejandro, Koeck, Thomas, Rapp, Steffen, Prochaska, Jürgen H., Spronk, Henri M., Wenzel, Philip, Ruf, Wolfram, ten Cate, Hugo, Wild, Philipp S., Panova-Noeva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563134/
https://www.ncbi.nlm.nih.gov/pubmed/32906769
http://dx.doi.org/10.3390/jcm9092892
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author Lagrange, Jeremy
Wagner, Bianca
Nagler, Markus
ten Cate, Vincent
Pallares Robles, Alejandro
Koeck, Thomas
Rapp, Steffen
Prochaska, Jürgen H.
Spronk, Henri M.
Wenzel, Philip
Ruf, Wolfram
ten Cate, Hugo
Wild, Philipp S.
Panova-Noeva, Marina
author_facet Lagrange, Jeremy
Wagner, Bianca
Nagler, Markus
ten Cate, Vincent
Pallares Robles, Alejandro
Koeck, Thomas
Rapp, Steffen
Prochaska, Jürgen H.
Spronk, Henri M.
Wenzel, Philip
Ruf, Wolfram
ten Cate, Hugo
Wild, Philipp S.
Panova-Noeva, Marina
author_sort Lagrange, Jeremy
collection PubMed
description Background. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. Results. Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. Conclusions. This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation.
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spelling pubmed-75631342020-10-27 Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients Lagrange, Jeremy Wagner, Bianca Nagler, Markus ten Cate, Vincent Pallares Robles, Alejandro Koeck, Thomas Rapp, Steffen Prochaska, Jürgen H. Spronk, Henri M. Wenzel, Philip Ruf, Wolfram ten Cate, Hugo Wild, Philipp S. Panova-Noeva, Marina J Clin Med Brief Report Background. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. Results. Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. Conclusions. This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation. MDPI 2020-09-07 /pmc/articles/PMC7563134/ /pubmed/32906769 http://dx.doi.org/10.3390/jcm9092892 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Lagrange, Jeremy
Wagner, Bianca
Nagler, Markus
ten Cate, Vincent
Pallares Robles, Alejandro
Koeck, Thomas
Rapp, Steffen
Prochaska, Jürgen H.
Spronk, Henri M.
Wenzel, Philip
Ruf, Wolfram
ten Cate, Hugo
Wild, Philipp S.
Panova-Noeva, Marina
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title_full Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title_fullStr Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title_full_unstemmed Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title_short Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
title_sort characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563134/
https://www.ncbi.nlm.nih.gov/pubmed/32906769
http://dx.doi.org/10.3390/jcm9092892
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