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Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians

Background: Cutaneous melanomas located on the acral part of extremities (hand and foot melanoma; HFM) comprise a rare group within all melanomas in Caucasians. HFM is associated with a poor prognosis. We aimed to evaluate clinicopathological features, long-term outcomes, and prognostic factors in p...

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Autores principales: Borkowska, Aneta M., Szumera-Ciećkiewicz, Anna, Spałek, Mateusz J., Teterycz, Paweł, Czarnecka, Anna M., Rutkowski, Piotr Ł.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563150/
https://www.ncbi.nlm.nih.gov/pubmed/32948014
http://dx.doi.org/10.3390/jcm9092996
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author Borkowska, Aneta M.
Szumera-Ciećkiewicz, Anna
Spałek, Mateusz J.
Teterycz, Paweł
Czarnecka, Anna M.
Rutkowski, Piotr Ł.
author_facet Borkowska, Aneta M.
Szumera-Ciećkiewicz, Anna
Spałek, Mateusz J.
Teterycz, Paweł
Czarnecka, Anna M.
Rutkowski, Piotr Ł.
author_sort Borkowska, Aneta M.
collection PubMed
description Background: Cutaneous melanomas located on the acral part of extremities (hand and foot melanoma; HFM) comprise a rare group within all melanomas in Caucasians. HFM is associated with a poor prognosis. We aimed to evaluate clinicopathological features, long-term outcomes, and prognostic factors in primary HFM in Caucasians. Methods: Medical records of all consecutive patients treated between 1997 and 2014 were revised. Patients were diagnosed with primary cutaneous melanoma at I-II clinical stage, and sentinel lymph node biopsy was conducted. The analysis was performed to define the clinicopathological factors influencing outcomes in the HFM and subungual cohort. Among 2537 consecutive patients diagnosed with primary cutaneous melanoma, 247 cases of HFM (9.7%) were found, with a median follow-up time of 7.8 years. Results: Median primary tumor Breslow thickness in subungual melanomas and HFMs was 4.0 mm and 3.3 mm, respectively, significantly higher than in the entire population (median 2.2 mm; p < 0.01). In the HFM group, 37.6% of tumors were ulcerated. Metastases to sentinel lymph node (SLN) were found in 28.3% of HFMs. The 10-year overall survival rate in the HFM group and subungual melanomas was 48.1% and 49.3%, respectively, compared to 63.0% in non-HFM melanomas. Conclusions: Our results confirm that patients with HFMs display worse overall survival compared to the entire melanoma population, with male gender and positive SLN biopsy status acting as independent negative prognostic factors.
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spelling pubmed-75631502020-10-27 Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians Borkowska, Aneta M. Szumera-Ciećkiewicz, Anna Spałek, Mateusz J. Teterycz, Paweł Czarnecka, Anna M. Rutkowski, Piotr Ł. J Clin Med Article Background: Cutaneous melanomas located on the acral part of extremities (hand and foot melanoma; HFM) comprise a rare group within all melanomas in Caucasians. HFM is associated with a poor prognosis. We aimed to evaluate clinicopathological features, long-term outcomes, and prognostic factors in primary HFM in Caucasians. Methods: Medical records of all consecutive patients treated between 1997 and 2014 were revised. Patients were diagnosed with primary cutaneous melanoma at I-II clinical stage, and sentinel lymph node biopsy was conducted. The analysis was performed to define the clinicopathological factors influencing outcomes in the HFM and subungual cohort. Among 2537 consecutive patients diagnosed with primary cutaneous melanoma, 247 cases of HFM (9.7%) were found, with a median follow-up time of 7.8 years. Results: Median primary tumor Breslow thickness in subungual melanomas and HFMs was 4.0 mm and 3.3 mm, respectively, significantly higher than in the entire population (median 2.2 mm; p < 0.01). In the HFM group, 37.6% of tumors were ulcerated. Metastases to sentinel lymph node (SLN) were found in 28.3% of HFMs. The 10-year overall survival rate in the HFM group and subungual melanomas was 48.1% and 49.3%, respectively, compared to 63.0% in non-HFM melanomas. Conclusions: Our results confirm that patients with HFMs display worse overall survival compared to the entire melanoma population, with male gender and positive SLN biopsy status acting as independent negative prognostic factors. MDPI 2020-09-16 /pmc/articles/PMC7563150/ /pubmed/32948014 http://dx.doi.org/10.3390/jcm9092996 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borkowska, Aneta M.
Szumera-Ciećkiewicz, Anna
Spałek, Mateusz J.
Teterycz, Paweł
Czarnecka, Anna M.
Rutkowski, Piotr Ł.
Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title_full Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title_fullStr Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title_full_unstemmed Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title_short Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians
title_sort clinicopathological features and prognostic factors of primary acral melanomas in caucasians
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563150/
https://www.ncbi.nlm.nih.gov/pubmed/32948014
http://dx.doi.org/10.3390/jcm9092996
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