Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer

Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis...

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Autores principales: Matsuo, Koji, Tanabe, Kazuhiro, Hayashi, Masaru, Ikeda, Masae, Yasaka, Miwa, Machida, Hiroko, Shida, Masako, Sato, Kenji, Yoshida, Hiroshi, Hirasawa, Takeshi, Imanishi, Tadashi, Mikami, Mikio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563232/
https://www.ncbi.nlm.nih.gov/pubmed/32825727
http://dx.doi.org/10.3390/cancers12092374
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author Matsuo, Koji
Tanabe, Kazuhiro
Hayashi, Masaru
Ikeda, Masae
Yasaka, Miwa
Machida, Hiroko
Shida, Masako
Sato, Kenji
Yoshida, Hiroshi
Hirasawa, Takeshi
Imanishi, Tadashi
Mikami, Mikio
author_facet Matsuo, Koji
Tanabe, Kazuhiro
Hayashi, Masaru
Ikeda, Masae
Yasaka, Miwa
Machida, Hiroko
Shida, Masako
Sato, Kenji
Yoshida, Hiroshi
Hirasawa, Takeshi
Imanishi, Tadashi
Mikami, Mikio
author_sort Matsuo, Koji
collection PubMed
description Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.
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spelling pubmed-75632322020-10-27 Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer Matsuo, Koji Tanabe, Kazuhiro Hayashi, Masaru Ikeda, Masae Yasaka, Miwa Machida, Hiroko Shida, Masako Sato, Kenji Yoshida, Hiroshi Hirasawa, Takeshi Imanishi, Tadashi Mikami, Mikio Cancers (Basel) Brief Report Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer. MDPI 2020-08-21 /pmc/articles/PMC7563232/ /pubmed/32825727 http://dx.doi.org/10.3390/cancers12092374 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Matsuo, Koji
Tanabe, Kazuhiro
Hayashi, Masaru
Ikeda, Masae
Yasaka, Miwa
Machida, Hiroko
Shida, Masako
Sato, Kenji
Yoshida, Hiroshi
Hirasawa, Takeshi
Imanishi, Tadashi
Mikami, Mikio
Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title_full Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title_fullStr Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title_full_unstemmed Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title_short Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer
title_sort utility of comprehensive serum glycopeptide spectra analysis (csgsa) for the detection of early stage epithelial ovarian cancer
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563232/
https://www.ncbi.nlm.nih.gov/pubmed/32825727
http://dx.doi.org/10.3390/cancers12092374
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