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Aorto-Iliac Artery Calcification Prior to Kidney Transplantation

As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification c...

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Autores principales: Benjamens, Stan, Rijkse, Elsaline, te Velde-Keyzer, Charlotte A., Berger, Stefan P., Moers, Cyril, de Borst, Martin H., Yakar, Derya, Slart, Riemer H. J. A., Dor, Frank J. M. F., Minnee, Robert C., Pol, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563260/
https://www.ncbi.nlm.nih.gov/pubmed/32906789
http://dx.doi.org/10.3390/jcm9092893
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author Benjamens, Stan
Rijkse, Elsaline
te Velde-Keyzer, Charlotte A.
Berger, Stefan P.
Moers, Cyril
de Borst, Martin H.
Yakar, Derya
Slart, Riemer H. J. A.
Dor, Frank J. M. F.
Minnee, Robert C.
Pol, Robert A.
author_facet Benjamens, Stan
Rijkse, Elsaline
te Velde-Keyzer, Charlotte A.
Berger, Stefan P.
Moers, Cyril
de Borst, Martin H.
Yakar, Derya
Slart, Riemer H. J. A.
Dor, Frank J. M. F.
Minnee, Robert C.
Pol, Robert A.
author_sort Benjamens, Stan
collection PubMed
description As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification can be used for cardiovascular risk stratification prior to kidney transplantation. In this dual-center cohort study, we measured the aorto-iliac calcium score (CaScore) of 547 patients within three years prior to transplantation (2005–2018). During a median (interquartile range) follow-up of 3.1 (1.4, 5.2) years after transplantation, 80 (14.7%) patients died, of which 32 (40.0%) died due to cardiovascular causes, and 84 (15.5%) patients had a cardiovascular event. Kaplan-Meier survival curves showed significant differences between the CaScore tertiles for cumulative overall-survival (Log-rank test p < 0.0001), cardiovascular survival (p < 0.0001), and cardiovascular event-free survival (p < 0.001). In multivariable Cox regression, the aorto-iliac CaScore was associated with all-cause mortality (hazard ratio 1.53, 95%CI 1.14–2.06, p = 0.005), cardiovascular mortality (2.04, 1.20–3.45, p = 0.008), and cardiovascular events (1.35, 1.01–1.80, p = 0.042). These independent associations of the aorto-iliac CaScore with the outcome measures can improve the identification of patients at risk for (cardiovascular) death and those who could potentially benefit from stringent cardiovascular monitoring to improve their prognosis after transplantation.
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spelling pubmed-75632602020-10-27 Aorto-Iliac Artery Calcification Prior to Kidney Transplantation Benjamens, Stan Rijkse, Elsaline te Velde-Keyzer, Charlotte A. Berger, Stefan P. Moers, Cyril de Borst, Martin H. Yakar, Derya Slart, Riemer H. J. A. Dor, Frank J. M. F. Minnee, Robert C. Pol, Robert A. J Clin Med Article As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification can be used for cardiovascular risk stratification prior to kidney transplantation. In this dual-center cohort study, we measured the aorto-iliac calcium score (CaScore) of 547 patients within three years prior to transplantation (2005–2018). During a median (interquartile range) follow-up of 3.1 (1.4, 5.2) years after transplantation, 80 (14.7%) patients died, of which 32 (40.0%) died due to cardiovascular causes, and 84 (15.5%) patients had a cardiovascular event. Kaplan-Meier survival curves showed significant differences between the CaScore tertiles for cumulative overall-survival (Log-rank test p < 0.0001), cardiovascular survival (p < 0.0001), and cardiovascular event-free survival (p < 0.001). In multivariable Cox regression, the aorto-iliac CaScore was associated with all-cause mortality (hazard ratio 1.53, 95%CI 1.14–2.06, p = 0.005), cardiovascular mortality (2.04, 1.20–3.45, p = 0.008), and cardiovascular events (1.35, 1.01–1.80, p = 0.042). These independent associations of the aorto-iliac CaScore with the outcome measures can improve the identification of patients at risk for (cardiovascular) death and those who could potentially benefit from stringent cardiovascular monitoring to improve their prognosis after transplantation. MDPI 2020-09-07 /pmc/articles/PMC7563260/ /pubmed/32906789 http://dx.doi.org/10.3390/jcm9092893 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benjamens, Stan
Rijkse, Elsaline
te Velde-Keyzer, Charlotte A.
Berger, Stefan P.
Moers, Cyril
de Borst, Martin H.
Yakar, Derya
Slart, Riemer H. J. A.
Dor, Frank J. M. F.
Minnee, Robert C.
Pol, Robert A.
Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title_full Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title_fullStr Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title_full_unstemmed Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title_short Aorto-Iliac Artery Calcification Prior to Kidney Transplantation
title_sort aorto-iliac artery calcification prior to kidney transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563260/
https://www.ncbi.nlm.nih.gov/pubmed/32906789
http://dx.doi.org/10.3390/jcm9092893
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