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Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563303/ https://www.ncbi.nlm.nih.gov/pubmed/32916988 http://dx.doi.org/10.3390/jcm9092910 |
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author | Lee, Seung Min Kim, Kwangsoo Yoon, Jihoon Park, Sue K. Moon, Sungji Lee, Sang Eun Oh, JiSeon Yoo, Sooyoung Kim, Kwang-Il Yoon, Hyung-Jin Lee, Hae-Young |
author_facet | Lee, Seung Min Kim, Kwangsoo Yoon, Jihoon Park, Sue K. Moon, Sungji Lee, Sang Eun Oh, JiSeon Yoo, Sooyoung Kim, Kwang-Il Yoon, Hyung-Jin Lee, Hae-Young |
author_sort | Lee, Seung Min |
collection | PubMed |
description | Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A retrospective multicenter observational study was conducted using a distributed research network to analyze the effect of HCTZ on skin cancer from 2004 to 2018. We performed Cox regression to evaluate the effects by comparing the use of HCTZ with other antihypertensive drugs. All analyses were re-evaluated using matched data using the propensity score matching (PSM). Then, the overall effects were evaluated by combining results with the meta-analysis. Results: Positive associations were observed in the use of HCTZ with high cumulative dose for non-melanoma skin cancer (NMSC) in univariate analysis prior to the use of PSM. Some negative associations were observed in the use of low and medium cumulative doses. Conclusion: Although many findings in our study were inconclusive, there was a non-significant association of a dose-response pattern with estimates increasing in cumulative dose of HCTZ. In particular, a trend with a non-significant positive association was observed with the high cumulative dose of HCTZ. |
format | Online Article Text |
id | pubmed-7563303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75633032020-10-27 Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population Lee, Seung Min Kim, Kwangsoo Yoon, Jihoon Park, Sue K. Moon, Sungji Lee, Sang Eun Oh, JiSeon Yoo, Sooyoung Kim, Kwang-Il Yoon, Hyung-Jin Lee, Hae-Young J Clin Med Article Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A retrospective multicenter observational study was conducted using a distributed research network to analyze the effect of HCTZ on skin cancer from 2004 to 2018. We performed Cox regression to evaluate the effects by comparing the use of HCTZ with other antihypertensive drugs. All analyses were re-evaluated using matched data using the propensity score matching (PSM). Then, the overall effects were evaluated by combining results with the meta-analysis. Results: Positive associations were observed in the use of HCTZ with high cumulative dose for non-melanoma skin cancer (NMSC) in univariate analysis prior to the use of PSM. Some negative associations were observed in the use of low and medium cumulative doses. Conclusion: Although many findings in our study were inconclusive, there was a non-significant association of a dose-response pattern with estimates increasing in cumulative dose of HCTZ. In particular, a trend with a non-significant positive association was observed with the high cumulative dose of HCTZ. MDPI 2020-09-09 /pmc/articles/PMC7563303/ /pubmed/32916988 http://dx.doi.org/10.3390/jcm9092910 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Seung Min Kim, Kwangsoo Yoon, Jihoon Park, Sue K. Moon, Sungji Lee, Sang Eun Oh, JiSeon Yoo, Sooyoung Kim, Kwang-Il Yoon, Hyung-Jin Lee, Hae-Young Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title | Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title_full | Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title_fullStr | Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title_full_unstemmed | Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title_short | Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population |
title_sort | association between use of hydrochlorothiazide and nonmelanoma skin cancer: common data model cohort study in asian population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563303/ https://www.ncbi.nlm.nih.gov/pubmed/32916988 http://dx.doi.org/10.3390/jcm9092910 |
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