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Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population

Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A...

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Autores principales: Lee, Seung Min, Kim, Kwangsoo, Yoon, Jihoon, Park, Sue K., Moon, Sungji, Lee, Sang Eun, Oh, JiSeon, Yoo, Sooyoung, Kim, Kwang-Il, Yoon, Hyung-Jin, Lee, Hae-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563303/
https://www.ncbi.nlm.nih.gov/pubmed/32916988
http://dx.doi.org/10.3390/jcm9092910
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author Lee, Seung Min
Kim, Kwangsoo
Yoon, Jihoon
Park, Sue K.
Moon, Sungji
Lee, Sang Eun
Oh, JiSeon
Yoo, Sooyoung
Kim, Kwang-Il
Yoon, Hyung-Jin
Lee, Hae-Young
author_facet Lee, Seung Min
Kim, Kwangsoo
Yoon, Jihoon
Park, Sue K.
Moon, Sungji
Lee, Sang Eun
Oh, JiSeon
Yoo, Sooyoung
Kim, Kwang-Il
Yoon, Hyung-Jin
Lee, Hae-Young
author_sort Lee, Seung Min
collection PubMed
description Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A retrospective multicenter observational study was conducted using a distributed research network to analyze the effect of HCTZ on skin cancer from 2004 to 2018. We performed Cox regression to evaluate the effects by comparing the use of HCTZ with other antihypertensive drugs. All analyses were re-evaluated using matched data using the propensity score matching (PSM). Then, the overall effects were evaluated by combining results with the meta-analysis. Results: Positive associations were observed in the use of HCTZ with high cumulative dose for non-melanoma skin cancer (NMSC) in univariate analysis prior to the use of PSM. Some negative associations were observed in the use of low and medium cumulative doses. Conclusion: Although many findings in our study were inconclusive, there was a non-significant association of a dose-response pattern with estimates increasing in cumulative dose of HCTZ. In particular, a trend with a non-significant positive association was observed with the high cumulative dose of HCTZ.
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spelling pubmed-75633032020-10-27 Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population Lee, Seung Min Kim, Kwangsoo Yoon, Jihoon Park, Sue K. Moon, Sungji Lee, Sang Eun Oh, JiSeon Yoo, Sooyoung Kim, Kwang-Il Yoon, Hyung-Jin Lee, Hae-Young J Clin Med Article Although hydrochlorothiazide (HCTZ) has been suggested to increase skin cancer risk in white Westerners, there is scant evidence for the same in Asians. We analyzed the association between the use of hydrochlorothiazide and non-melanoma in the Asian population using the common data model. Methods: A retrospective multicenter observational study was conducted using a distributed research network to analyze the effect of HCTZ on skin cancer from 2004 to 2018. We performed Cox regression to evaluate the effects by comparing the use of HCTZ with other antihypertensive drugs. All analyses were re-evaluated using matched data using the propensity score matching (PSM). Then, the overall effects were evaluated by combining results with the meta-analysis. Results: Positive associations were observed in the use of HCTZ with high cumulative dose for non-melanoma skin cancer (NMSC) in univariate analysis prior to the use of PSM. Some negative associations were observed in the use of low and medium cumulative doses. Conclusion: Although many findings in our study were inconclusive, there was a non-significant association of a dose-response pattern with estimates increasing in cumulative dose of HCTZ. In particular, a trend with a non-significant positive association was observed with the high cumulative dose of HCTZ. MDPI 2020-09-09 /pmc/articles/PMC7563303/ /pubmed/32916988 http://dx.doi.org/10.3390/jcm9092910 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Seung Min
Kim, Kwangsoo
Yoon, Jihoon
Park, Sue K.
Moon, Sungji
Lee, Sang Eun
Oh, JiSeon
Yoo, Sooyoung
Kim, Kwang-Il
Yoon, Hyung-Jin
Lee, Hae-Young
Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title_full Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title_fullStr Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title_full_unstemmed Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title_short Association between Use of Hydrochlorothiazide and Nonmelanoma Skin Cancer: Common Data Model Cohort Study in Asian Population
title_sort association between use of hydrochlorothiazide and nonmelanoma skin cancer: common data model cohort study in asian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563303/
https://www.ncbi.nlm.nih.gov/pubmed/32916988
http://dx.doi.org/10.3390/jcm9092910
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