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Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer
In locally advanced rectal cancer, radiotherapy (RT) followed by surgery have improved locoregional control, but distant recurrences remain frequent. Although checkpoint inhibitors have demonstrated objective response in several cancers, the clinical benefit of PD-1/PD-L1 blockade remains uncertain...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563314/ https://www.ncbi.nlm.nih.gov/pubmed/32927784 http://dx.doi.org/10.3390/cells9092071 |
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author | Boustani, Jihane Derangère, Valentin Bertaut, Aurélie Adotevi, Olivier Morgand, Véronique Charon-Barra, Céline Ghiringhelli, François Mirjolet, Céline |
author_facet | Boustani, Jihane Derangère, Valentin Bertaut, Aurélie Adotevi, Olivier Morgand, Véronique Charon-Barra, Céline Ghiringhelli, François Mirjolet, Céline |
author_sort | Boustani, Jihane |
collection | PubMed |
description | In locally advanced rectal cancer, radiotherapy (RT) followed by surgery have improved locoregional control, but distant recurrences remain frequent. Although checkpoint inhibitors have demonstrated objective response in several cancers, the clinical benefit of PD-1/PD-L1 blockade remains uncertain in rectal cancer. We collected data from biopsies and surgical specimens in 74 patients. The main objective was to evaluate the impact of neoadjuvant RT and fractionation on PD-L1 expression. Secondary objectives were to study the relation between PD-L1 expression and tumor regression grade (TRG), progression-free survival (PFS), overall survival (OS), and CD8 TILs infiltration. Median rates of cells expressing PD-L1 pre- and post-RT were 0.15 (range, 0–17) and 0.5 (range, 0–27.5), respectively (p = 0.0005). There was no effect of RT fractionation on PD-L1+ cell rates. We found no relation between CD8+ TILs infiltration and PD-L1 expression and no difference between high-PD-L1 or low-PD-L1 expression and TRG. High-to-high PD-L1 expression profile had none significant higher OS and PFS compared to all other groups (p = 0.06). Median OS and PFS were higher in biopsies with >0.08 PD-L1+ cells. High-to-high PD-L1 profile and ypT0-2 were significantly associated with higher OS and PFS. This study did not show the differential induction of PD-L1 expression according to fractionation. |
format | Online Article Text |
id | pubmed-7563314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75633142020-10-27 Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer Boustani, Jihane Derangère, Valentin Bertaut, Aurélie Adotevi, Olivier Morgand, Véronique Charon-Barra, Céline Ghiringhelli, François Mirjolet, Céline Cells Article In locally advanced rectal cancer, radiotherapy (RT) followed by surgery have improved locoregional control, but distant recurrences remain frequent. Although checkpoint inhibitors have demonstrated objective response in several cancers, the clinical benefit of PD-1/PD-L1 blockade remains uncertain in rectal cancer. We collected data from biopsies and surgical specimens in 74 patients. The main objective was to evaluate the impact of neoadjuvant RT and fractionation on PD-L1 expression. Secondary objectives were to study the relation between PD-L1 expression and tumor regression grade (TRG), progression-free survival (PFS), overall survival (OS), and CD8 TILs infiltration. Median rates of cells expressing PD-L1 pre- and post-RT were 0.15 (range, 0–17) and 0.5 (range, 0–27.5), respectively (p = 0.0005). There was no effect of RT fractionation on PD-L1+ cell rates. We found no relation between CD8+ TILs infiltration and PD-L1 expression and no difference between high-PD-L1 or low-PD-L1 expression and TRG. High-to-high PD-L1 expression profile had none significant higher OS and PFS compared to all other groups (p = 0.06). Median OS and PFS were higher in biopsies with >0.08 PD-L1+ cells. High-to-high PD-L1 profile and ypT0-2 were significantly associated with higher OS and PFS. This study did not show the differential induction of PD-L1 expression according to fractionation. MDPI 2020-09-10 /pmc/articles/PMC7563314/ /pubmed/32927784 http://dx.doi.org/10.3390/cells9092071 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boustani, Jihane Derangère, Valentin Bertaut, Aurélie Adotevi, Olivier Morgand, Véronique Charon-Barra, Céline Ghiringhelli, François Mirjolet, Céline Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title | Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title_full | Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title_fullStr | Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title_full_unstemmed | Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title_short | Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer |
title_sort | radiotherapy scheme effect on pd-l1 expression for locally advanced rectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563314/ https://www.ncbi.nlm.nih.gov/pubmed/32927784 http://dx.doi.org/10.3390/cells9092071 |
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