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Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities
The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, nam...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563331/ https://www.ncbi.nlm.nih.gov/pubmed/32899793 http://dx.doi.org/10.3390/cells9092033 |
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author | Musarò, Antonio |
author_facet | Musarò, Antonio |
author_sort | Musarò, Antonio |
collection | PubMed |
description | The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit the damaged tissues from efficiently activating a regenerative program. It is, therefore, plausible that the loss of control over these cells’ fate might lead to pathological cell differentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. This Special Issue aims to bring together a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration and to suggest potential therapeutic approaches for degenerating muscle disease. |
format | Online Article Text |
id | pubmed-7563331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75633312020-10-27 Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities Musarò, Antonio Cells Editorial The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit the damaged tissues from efficiently activating a regenerative program. It is, therefore, plausible that the loss of control over these cells’ fate might lead to pathological cell differentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. This Special Issue aims to bring together a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration and to suggest potential therapeutic approaches for degenerating muscle disease. MDPI 2020-09-04 /pmc/articles/PMC7563331/ /pubmed/32899793 http://dx.doi.org/10.3390/cells9092033 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Musarò, Antonio Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title | Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title_full | Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title_fullStr | Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title_full_unstemmed | Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title_short | Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities |
title_sort | muscle homeostasis and regeneration: from molecular mechanisms to therapeutic opportunities |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563331/ https://www.ncbi.nlm.nih.gov/pubmed/32899793 http://dx.doi.org/10.3390/cells9092033 |
work_keys_str_mv | AT musaroantonio musclehomeostasisandregenerationfrommolecularmechanismstotherapeuticopportunities |