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Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome
Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563376/ https://www.ncbi.nlm.nih.gov/pubmed/32967202 http://dx.doi.org/10.3390/jcm9093037 |
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author | Franco-Peláez, Juan Antonio Martín-Reyes, Roberto Pello-Lázaro, Ana María Aceña, Álvaro Lorenzo, Óscar Martín-Ventura, José Luis Blanco-Colio, Luis González-Casaus, María Luisa Hernández-González, Ignacio Carda, Rocío Martín-Mariscal, María Luisa Egido, Jesús Tuñón, José |
author_facet | Franco-Peláez, Juan Antonio Martín-Reyes, Roberto Pello-Lázaro, Ana María Aceña, Álvaro Lorenzo, Óscar Martín-Ventura, José Luis Blanco-Colio, Luis González-Casaus, María Luisa Hernández-González, Ignacio Carda, Rocío Martín-Mariscal, María Luisa Egido, Jesús Tuñón, José |
author_sort | Franco-Peláez, Juan Antonio |
collection | PubMed |
description | Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an acute coronary syndrome 6 months before. Plasma levels of several biomarkers were assessed, and patients were followed during a median of 5.35 (3.88–6.65) years. Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = (1.35–3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor of CAE, whereas mineral metabolism markers or proprotein convertase subtilisin/kexin type 9 were not. Moreover, CAE was a strong predictor of AAT during follow-up after adjustment for other clinically relevant variables (HR = 2.67, 95%CI = (1.22–5.82), p = 0.013). This is the first report showing that MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery disease may share pathogenic mechanisms. Furthermore, CAE was associated with an increased incidence of AAT. |
format | Online Article Text |
id | pubmed-7563376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75633762020-10-27 Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome Franco-Peláez, Juan Antonio Martín-Reyes, Roberto Pello-Lázaro, Ana María Aceña, Álvaro Lorenzo, Óscar Martín-Ventura, José Luis Blanco-Colio, Luis González-Casaus, María Luisa Hernández-González, Ignacio Carda, Rocío Martín-Mariscal, María Luisa Egido, Jesús Tuñón, José J Clin Med Article Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an acute coronary syndrome 6 months before. Plasma levels of several biomarkers were assessed, and patients were followed during a median of 5.35 (3.88–6.65) years. Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = (1.35–3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor of CAE, whereas mineral metabolism markers or proprotein convertase subtilisin/kexin type 9 were not. Moreover, CAE was a strong predictor of AAT during follow-up after adjustment for other clinically relevant variables (HR = 2.67, 95%CI = (1.22–5.82), p = 0.013). This is the first report showing that MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery disease may share pathogenic mechanisms. Furthermore, CAE was associated with an increased incidence of AAT. MDPI 2020-09-21 /pmc/articles/PMC7563376/ /pubmed/32967202 http://dx.doi.org/10.3390/jcm9093037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Franco-Peláez, Juan Antonio Martín-Reyes, Roberto Pello-Lázaro, Ana María Aceña, Álvaro Lorenzo, Óscar Martín-Ventura, José Luis Blanco-Colio, Luis González-Casaus, María Luisa Hernández-González, Ignacio Carda, Rocío Martín-Mariscal, María Luisa Egido, Jesús Tuñón, José Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title | Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title_full | Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title_fullStr | Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title_full_unstemmed | Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title_short | Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome |
title_sort | monocyte chemoattractant protein-1 is an independent predictor of coronary artery ectasia in patients with acute coronary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563376/ https://www.ncbi.nlm.nih.gov/pubmed/32967202 http://dx.doi.org/10.3390/jcm9093037 |
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