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Entosis: From Cell Biology to Clinical Cancer Pathology

SIMPLE SUMMARY: We review published clinico-histopathological studies establishing entosis an important prognostic and predictor factor in various cancer types. We also propose a new model to study this phenomenon, which involves active entry of one cell into another one. The internalized cell can r...

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Autores principales: Mlynarczuk-Bialy, Izabela, Dziuba, Ireneusz, Sarnecka, Agnieszka, Platos, Emilia, Kowalczyk, Magdalena, Pels, Katarzyna K., Wilczynski, Grzegorz M., Wojcik, Cezary, Bialy, Lukasz P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563411/
https://www.ncbi.nlm.nih.gov/pubmed/32883000
http://dx.doi.org/10.3390/cancers12092481
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author Mlynarczuk-Bialy, Izabela
Dziuba, Ireneusz
Sarnecka, Agnieszka
Platos, Emilia
Kowalczyk, Magdalena
Pels, Katarzyna K.
Wilczynski, Grzegorz M.
Wojcik, Cezary
Bialy, Lukasz P.
author_facet Mlynarczuk-Bialy, Izabela
Dziuba, Ireneusz
Sarnecka, Agnieszka
Platos, Emilia
Kowalczyk, Magdalena
Pels, Katarzyna K.
Wilczynski, Grzegorz M.
Wojcik, Cezary
Bialy, Lukasz P.
author_sort Mlynarczuk-Bialy, Izabela
collection PubMed
description SIMPLE SUMMARY: We review published clinico-histopathological studies establishing entosis an important prognostic and predictor factor in various cancer types. We also propose a new model to study this phenomenon, which involves active entry of one cell into another one. The internalized cell can remain viable and leave the host cell after a long time, potentially leading to cancer recurrence. Entotic figures are cell in cell structures, in which the nucleus of external cell is crescent-shaped, and the inner cell is surrounded by the extensive space entotic vacuole, distinguishing entosis from cell cannibalism. Entosis correlates with cancer worse prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma, and some breast ductal carcinoma. The BxPC-3 pancreatic cancer cells provide a new, more convenient model for entosis research in comparison to the previously described semidherent MCF7 model. BxPC-3 cells undergo and survive spontaneous entosis in normal adherent culture conditions. ABSTRACT: Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.
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spelling pubmed-75634112020-10-27 Entosis: From Cell Biology to Clinical Cancer Pathology Mlynarczuk-Bialy, Izabela Dziuba, Ireneusz Sarnecka, Agnieszka Platos, Emilia Kowalczyk, Magdalena Pels, Katarzyna K. Wilczynski, Grzegorz M. Wojcik, Cezary Bialy, Lukasz P. Cancers (Basel) Review SIMPLE SUMMARY: We review published clinico-histopathological studies establishing entosis an important prognostic and predictor factor in various cancer types. We also propose a new model to study this phenomenon, which involves active entry of one cell into another one. The internalized cell can remain viable and leave the host cell after a long time, potentially leading to cancer recurrence. Entotic figures are cell in cell structures, in which the nucleus of external cell is crescent-shaped, and the inner cell is surrounded by the extensive space entotic vacuole, distinguishing entosis from cell cannibalism. Entosis correlates with cancer worse prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma, and some breast ductal carcinoma. The BxPC-3 pancreatic cancer cells provide a new, more convenient model for entosis research in comparison to the previously described semidherent MCF7 model. BxPC-3 cells undergo and survive spontaneous entosis in normal adherent culture conditions. ABSTRACT: Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis. MDPI 2020-09-01 /pmc/articles/PMC7563411/ /pubmed/32883000 http://dx.doi.org/10.3390/cancers12092481 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mlynarczuk-Bialy, Izabela
Dziuba, Ireneusz
Sarnecka, Agnieszka
Platos, Emilia
Kowalczyk, Magdalena
Pels, Katarzyna K.
Wilczynski, Grzegorz M.
Wojcik, Cezary
Bialy, Lukasz P.
Entosis: From Cell Biology to Clinical Cancer Pathology
title Entosis: From Cell Biology to Clinical Cancer Pathology
title_full Entosis: From Cell Biology to Clinical Cancer Pathology
title_fullStr Entosis: From Cell Biology to Clinical Cancer Pathology
title_full_unstemmed Entosis: From Cell Biology to Clinical Cancer Pathology
title_short Entosis: From Cell Biology to Clinical Cancer Pathology
title_sort entosis: from cell biology to clinical cancer pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563411/
https://www.ncbi.nlm.nih.gov/pubmed/32883000
http://dx.doi.org/10.3390/cancers12092481
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