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The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer
The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patient...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563514/ https://www.ncbi.nlm.nih.gov/pubmed/32933192 http://dx.doi.org/10.3390/jcm9092960 |
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author | Noh, Joseph J. Lim, Myong Cheol Kim, Moon-Hong Kim, Yun Hwan Song, Eun Seop Seong, Seok Ju Suh, Dong Hoon Lee, Jong-Min Lee, Chulmin Choi, Chel Hun |
author_facet | Noh, Joseph J. Lim, Myong Cheol Kim, Moon-Hong Kim, Yun Hwan Song, Eun Seop Seong, Seok Ju Suh, Dong Hoon Lee, Jong-Min Lee, Chulmin Choi, Chel Hun |
author_sort | Noh, Joseph J. |
collection | PubMed |
description | The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patients from nine tertiary medical centers in South Korea who were treated surgically for early stage cervical cancer were reviewed. Statistical models by the Akaike’s information criterion (AIC) were developed using CBC profiles to calculate individuals’ risk scores for clinical outcomes. A total of 1443 patients were included in the study and the median follow-up was 63.7 months with a range of 3–183 months. Univariate analyses identified the components of CBC that were significantly related to clinical outcomes including white blood cell (WBC), hemoglobin, neutrophil, and platelet levels. The models developed using CBC profiles and the conventional clinical predictive factors provided individuals’ risk scores that were significantly better in predicting clinical outcomes than the models using the conventional clinical predictive factors alone. Pre-treatment CBC profiles including WBC, hemoglobin, neutrophil, lymphocyte, and platelet levels were found to be a potential biomarker for survival prognosis in early cervical cancer. |
format | Online Article Text |
id | pubmed-7563514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75635142020-10-27 The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer Noh, Joseph J. Lim, Myong Cheol Kim, Moon-Hong Kim, Yun Hwan Song, Eun Seop Seong, Seok Ju Suh, Dong Hoon Lee, Jong-Min Lee, Chulmin Choi, Chel Hun J Clin Med Article The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patients from nine tertiary medical centers in South Korea who were treated surgically for early stage cervical cancer were reviewed. Statistical models by the Akaike’s information criterion (AIC) were developed using CBC profiles to calculate individuals’ risk scores for clinical outcomes. A total of 1443 patients were included in the study and the median follow-up was 63.7 months with a range of 3–183 months. Univariate analyses identified the components of CBC that were significantly related to clinical outcomes including white blood cell (WBC), hemoglobin, neutrophil, and platelet levels. The models developed using CBC profiles and the conventional clinical predictive factors provided individuals’ risk scores that were significantly better in predicting clinical outcomes than the models using the conventional clinical predictive factors alone. Pre-treatment CBC profiles including WBC, hemoglobin, neutrophil, lymphocyte, and platelet levels were found to be a potential biomarker for survival prognosis in early cervical cancer. MDPI 2020-09-13 /pmc/articles/PMC7563514/ /pubmed/32933192 http://dx.doi.org/10.3390/jcm9092960 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noh, Joseph J. Lim, Myong Cheol Kim, Moon-Hong Kim, Yun Hwan Song, Eun Seop Seong, Seok Ju Suh, Dong Hoon Lee, Jong-Min Lee, Chulmin Choi, Chel Hun The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title | The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title_full | The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title_fullStr | The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title_full_unstemmed | The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title_short | The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer |
title_sort | prognostic model of pre-treatment complete blood count (cbc) for recurrence in early cervical cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563514/ https://www.ncbi.nlm.nih.gov/pubmed/32933192 http://dx.doi.org/10.3390/jcm9092960 |
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