A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an alternative spliced isoform: ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim peptides to be loaded on MHC class I molecules, but it can still dimerize with both ERAP2-wt and ERAP1-wt, thus contributing t...

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Detalles Bibliográficos
Autores principales: Saulle, Irma, Vanetti, Claudia, Goglia, Sara, Vicentini, Chiara, Tombetti, Enrico, Garziano, Micaela, Clerici, Mario, Biasin, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563522/
https://www.ncbi.nlm.nih.gov/pubmed/32847031
http://dx.doi.org/10.3390/cells9091951

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