Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

Obesity is linked with altered microbial short-chain fatty acids (SCFAs), which are a signature of gut dysbiosis and inflammation. In the present study, we investigated whether tributyrin, a prodrug of the SCFA butyrate, could improve metabolic and inflammatory profiles in diet-induced obese mice. M...

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Detalles Bibliográficos
Autores principales: Sato, Fabio Takeo, Yap, Yu Anne, Crisma, Amanda Rabello, Portovedo, Mariana, Murata, Gilson Masahiro, Hirabara, Sandro Massao, Ribeiro, Willian Rodrigues, Marcantonio Ferreira, Caroline, Cruz, Maysa Mariana, Pereira, Joice Naiara Bertaglia, Payolla, Tanyara Baliani, Guima, Suzana Eiko Sato, Thomas, Andrew Maltez, Setubal, João Carlos, Alonso-Vale, Maria Isabel Cardoso, Santos, Marinilce Fagundes, Curi, Rui, Marino, Eliana, Vinolo, Marco A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563536/
https://www.ncbi.nlm.nih.gov/pubmed/32882837
http://dx.doi.org/10.3390/cells9092007

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