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From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

Many devastating neurodegenerative diseases are driven by the misfolding of normal proteins into a pathogenic abnormal conformation. Examples of such protein misfolding diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and prion diseases....

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Detalles Bibliográficos
Autores principales:	Marrero-Winkens, Cristóbal, Sankaran, Charu, Schätzl, Hermann M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563560/ https://www.ncbi.nlm.nih.gov/pubmed/32927676 http://dx.doi.org/10.3390/biom10091305

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