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Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial

SIMPLE SUMMARY: Identifying breast cancer patients with pathogenic mutations that run in their families may improve the follow-up care they receive and breast cancer screening of their close relatives. In this study we identified breast cancer patients with high chances of having a pathogenic mutati...

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Autores principales: Katapodi, Maria C., Ming, Chang, Northouse, Laurel L., Duffy, Sonia A., Duquette, Debra, Mendelsohn-Victor, Kari E., Milliron, Kara J., Merajver, Sofia D., Dinov, Ivo D., Janz, Nancy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563571/
https://www.ncbi.nlm.nih.gov/pubmed/32899538
http://dx.doi.org/10.3390/cancers12092526
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author Katapodi, Maria C.
Ming, Chang
Northouse, Laurel L.
Duffy, Sonia A.
Duquette, Debra
Mendelsohn-Victor, Kari E.
Milliron, Kara J.
Merajver, Sofia D.
Dinov, Ivo D.
Janz, Nancy K.
author_facet Katapodi, Maria C.
Ming, Chang
Northouse, Laurel L.
Duffy, Sonia A.
Duquette, Debra
Mendelsohn-Victor, Kari E.
Milliron, Kara J.
Merajver, Sofia D.
Dinov, Ivo D.
Janz, Nancy K.
author_sort Katapodi, Maria C.
collection PubMed
description SIMPLE SUMMARY: Identifying breast cancer patients with pathogenic mutations that run in their families may improve the follow-up care they receive and breast cancer screening of their close relatives. In this study we identified breast cancer patients with high chances of having a pathogenic mutation and their close female relatives. We developed and tested two different kinds of letters and booklets that presented either personalized or generic information about screening and breast cancer that runs in families, and we encouraged participants to seek genetic evaluation. We found that both types of letters worked equally well for breast cancer patients and for relatives, regardless of their racial background. The personalized letters had slightly better outcomes. Some breast cancer patients and their relatives used genetic services and improved their screening practices. Black patients and their relatives were more satisfied with the booklets than other participants. ABSTRACT: We compared a tailored and a targeted intervention designed to increase genetic testing, clinical breast exam (CBE), and mammography in young breast cancer survivors (YBCS) (diagnosed <45 years old) and their blood relatives. A two-arm cluster randomized trial recruited a random sample of YBCS from the Michigan cancer registry and up to two of their blood relatives. Participants were stratified according to race and randomly assigned as family units to the tailored (n = 637) or the targeted (n = 595) intervention. Approximately 40% of participants were Black. Based on intention-to-treat analyses, YBCS in the tailored arm reported higher self-efficacy for genetic services (p = 0.0205) at 8-months follow-up. Genetic testing increased approximately 5% for YBCS in the tailored and the targeted arm (p ≤ 0.001; p < 0.001) and for Black and White/Other YBCS (p < 0.001; p < 0.001). CBEs and mammograms increased significantly in both arms, 5% for YBCS and 10% for relatives and were similar for Blacks and White/Others. YBCS and relatives needing less support from providers reported significantly higher self-efficacy and intention for genetic testing and surveillance. Black participants reported significantly higher satisfaction and acceptability. Effects of these two low-resource interventions were comparable to previous studies. Materials are suitable for Black women at risk for hereditary breast/ovarian cancer (HBOC).
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spelling pubmed-75635712020-10-27 Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial Katapodi, Maria C. Ming, Chang Northouse, Laurel L. Duffy, Sonia A. Duquette, Debra Mendelsohn-Victor, Kari E. Milliron, Kara J. Merajver, Sofia D. Dinov, Ivo D. Janz, Nancy K. Cancers (Basel) Article SIMPLE SUMMARY: Identifying breast cancer patients with pathogenic mutations that run in their families may improve the follow-up care they receive and breast cancer screening of their close relatives. In this study we identified breast cancer patients with high chances of having a pathogenic mutation and their close female relatives. We developed and tested two different kinds of letters and booklets that presented either personalized or generic information about screening and breast cancer that runs in families, and we encouraged participants to seek genetic evaluation. We found that both types of letters worked equally well for breast cancer patients and for relatives, regardless of their racial background. The personalized letters had slightly better outcomes. Some breast cancer patients and their relatives used genetic services and improved their screening practices. Black patients and their relatives were more satisfied with the booklets than other participants. ABSTRACT: We compared a tailored and a targeted intervention designed to increase genetic testing, clinical breast exam (CBE), and mammography in young breast cancer survivors (YBCS) (diagnosed <45 years old) and their blood relatives. A two-arm cluster randomized trial recruited a random sample of YBCS from the Michigan cancer registry and up to two of their blood relatives. Participants were stratified according to race and randomly assigned as family units to the tailored (n = 637) or the targeted (n = 595) intervention. Approximately 40% of participants were Black. Based on intention-to-treat analyses, YBCS in the tailored arm reported higher self-efficacy for genetic services (p = 0.0205) at 8-months follow-up. Genetic testing increased approximately 5% for YBCS in the tailored and the targeted arm (p ≤ 0.001; p < 0.001) and for Black and White/Other YBCS (p < 0.001; p < 0.001). CBEs and mammograms increased significantly in both arms, 5% for YBCS and 10% for relatives and were similar for Blacks and White/Others. YBCS and relatives needing less support from providers reported significantly higher self-efficacy and intention for genetic testing and surveillance. Black participants reported significantly higher satisfaction and acceptability. Effects of these two low-resource interventions were comparable to previous studies. Materials are suitable for Black women at risk for hereditary breast/ovarian cancer (HBOC). MDPI 2020-09-05 /pmc/articles/PMC7563571/ /pubmed/32899538 http://dx.doi.org/10.3390/cancers12092526 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Katapodi, Maria C.
Ming, Chang
Northouse, Laurel L.
Duffy, Sonia A.
Duquette, Debra
Mendelsohn-Victor, Kari E.
Milliron, Kara J.
Merajver, Sofia D.
Dinov, Ivo D.
Janz, Nancy K.
Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title_full Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title_fullStr Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title_full_unstemmed Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title_short Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial
title_sort genetic testing and surveillance of young breast cancer survivors and blood relatives: a cluster randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563571/
https://www.ncbi.nlm.nih.gov/pubmed/32899538
http://dx.doi.org/10.3390/cancers12092526
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