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What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population?
Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. W...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563734/ https://www.ncbi.nlm.nih.gov/pubmed/32947828 http://dx.doi.org/10.3390/jcm9092988 |
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author | Park, Yoon Jung Yang, Pil-Sung Yu, Hee Tae Kim, Tae-Hoon Jang, Eunsun Uhm, Jae-Sun Pak, Hui-Nam Lee, Moon-Hyoung Lip, Gregory Y.H. Joung, Boyoung |
author_facet | Park, Yoon Jung Yang, Pil-Sung Yu, Hee Tae Kim, Tae-Hoon Jang, Eunsun Uhm, Jae-Sun Pak, Hui-Nam Lee, Moon-Hyoung Lip, Gregory Y.H. Joung, Boyoung |
author_sort | Park, Yoon Jung |
collection | PubMed |
description | Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. We included 115,866 participants without AF in the Korea National Health Insurance Service-Senior (≥60 years) cohort from 2002 to 2013. We compared the influence of BP on the occurrence of new-onset AF between octogenarians (≥80 years) and non-octogenarians (<80 years) subjects. With up to 6.7 ± 1.7 years of follow-up, 4393 incident AF cases occurred. After multivariable adjustment for potentially confounding clinical covariates, the risk of AF in non-octogenarians was significantly higher in subjects with BP levels of <120/<80 and ≥140/90 mm Hg, with hazard ratios of 1.15 (95% confidence interval (CI), 1.03–1.28; p < 0.001) and 1.14 (95% CI, 1.04–1.26; p < 0.001), compared to the optimal BP levels (120–129/<80 mm Hg). In octogenarians, the optimal BP range was 130–139/80–89 mm Hg, higher than in non-octogenarians. A U-shaped relationship for the development of incident AF was evident in non-octogenarians, and BP levels of 120–129/<80 mm Hg were associated the lowest risk of incident AF. Compared to non-octogenarians, the lowest risk of AF was associated with higher BP levels of 130–139/80–89 mm Hg amongst octogenarians. |
format | Online Article Text |
id | pubmed-7563734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75637342020-10-27 What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? Park, Yoon Jung Yang, Pil-Sung Yu, Hee Tae Kim, Tae-Hoon Jang, Eunsun Uhm, Jae-Sun Pak, Hui-Nam Lee, Moon-Hyoung Lip, Gregory Y.H. Joung, Boyoung J Clin Med Article Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. We included 115,866 participants without AF in the Korea National Health Insurance Service-Senior (≥60 years) cohort from 2002 to 2013. We compared the influence of BP on the occurrence of new-onset AF between octogenarians (≥80 years) and non-octogenarians (<80 years) subjects. With up to 6.7 ± 1.7 years of follow-up, 4393 incident AF cases occurred. After multivariable adjustment for potentially confounding clinical covariates, the risk of AF in non-octogenarians was significantly higher in subjects with BP levels of <120/<80 and ≥140/90 mm Hg, with hazard ratios of 1.15 (95% confidence interval (CI), 1.03–1.28; p < 0.001) and 1.14 (95% CI, 1.04–1.26; p < 0.001), compared to the optimal BP levels (120–129/<80 mm Hg). In octogenarians, the optimal BP range was 130–139/80–89 mm Hg, higher than in non-octogenarians. A U-shaped relationship for the development of incident AF was evident in non-octogenarians, and BP levels of 120–129/<80 mm Hg were associated the lowest risk of incident AF. Compared to non-octogenarians, the lowest risk of AF was associated with higher BP levels of 130–139/80–89 mm Hg amongst octogenarians. MDPI 2020-09-16 /pmc/articles/PMC7563734/ /pubmed/32947828 http://dx.doi.org/10.3390/jcm9092988 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, Yoon Jung Yang, Pil-Sung Yu, Hee Tae Kim, Tae-Hoon Jang, Eunsun Uhm, Jae-Sun Pak, Hui-Nam Lee, Moon-Hyoung Lip, Gregory Y.H. Joung, Boyoung What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title | What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title_full | What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title_fullStr | What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title_full_unstemmed | What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title_short | What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population? |
title_sort | what is the ideal blood pressure threshold for the prevention of atrial fibrillation in elderly general population? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563734/ https://www.ncbi.nlm.nih.gov/pubmed/32947828 http://dx.doi.org/10.3390/jcm9092988 |
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