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Role of Sodium/Calcium Exchangers in Tumors

The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted—calci...

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Autores principales: Chovancova, Barbora, Liskova, Veronika, Babula, Petr, Krizanova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563772/
https://www.ncbi.nlm.nih.gov/pubmed/32878087
http://dx.doi.org/10.3390/biom10091257
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author Chovancova, Barbora
Liskova, Veronika
Babula, Petr
Krizanova, Olga
author_facet Chovancova, Barbora
Liskova, Veronika
Babula, Petr
Krizanova, Olga
author_sort Chovancova, Barbora
collection PubMed
description The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted—calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.
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spelling pubmed-75637722020-10-27 Role of Sodium/Calcium Exchangers in Tumors Chovancova, Barbora Liskova, Veronika Babula, Petr Krizanova, Olga Biomolecules Review The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted—calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells. MDPI 2020-08-31 /pmc/articles/PMC7563772/ /pubmed/32878087 http://dx.doi.org/10.3390/biom10091257 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chovancova, Barbora
Liskova, Veronika
Babula, Petr
Krizanova, Olga
Role of Sodium/Calcium Exchangers in Tumors
title Role of Sodium/Calcium Exchangers in Tumors
title_full Role of Sodium/Calcium Exchangers in Tumors
title_fullStr Role of Sodium/Calcium Exchangers in Tumors
title_full_unstemmed Role of Sodium/Calcium Exchangers in Tumors
title_short Role of Sodium/Calcium Exchangers in Tumors
title_sort role of sodium/calcium exchangers in tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563772/
https://www.ncbi.nlm.nih.gov/pubmed/32878087
http://dx.doi.org/10.3390/biom10091257
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