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Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study

BACKGROUND: The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. METHODS AND RESULTS: A total of 1,254 COVID-19 patients comprising 124 (9.9%) hypon...

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Autores principales: Hu, Weihua, lv, Xinke, Li, Chang, Xu, Yang, Qi, Yiding, Zhang, Zhuheng, Li, Mingxuan, Cai, Feina, Liu, Dan, Yue, Jiang, Ye, Maoqing, Chen, Qijian, Shi, Kailei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563904/
https://www.ncbi.nlm.nih.gov/pubmed/33064253
http://dx.doi.org/10.1007/s11739-020-02515-9
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author Hu, Weihua
lv, Xinke
Li, Chang
Xu, Yang
Qi, Yiding
Zhang, Zhuheng
Li, Mingxuan
Cai, Feina
Liu, Dan
Yue, Jiang
Ye, Maoqing
Chen, Qijian
Shi, Kailei
author_facet Hu, Weihua
lv, Xinke
Li, Chang
Xu, Yang
Qi, Yiding
Zhang, Zhuheng
Li, Mingxuan
Cai, Feina
Liu, Dan
Yue, Jiang
Ye, Maoqing
Chen, Qijian
Shi, Kailei
author_sort Hu, Weihua
collection PubMed
description BACKGROUND: The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. METHODS AND RESULTS: A total of 1,254 COVID-19 patients comprising 124 (9.9%) hyponatremic patients (under 135 mmol/L) and 30 (2.4%) hypernatremic patients (over 145 mmol/L) from three hospitals in Hubei, China, were enrolled in the study. The relationships between sodium balance disorders in COVID-19 patients, its clinical features, implications, and the underlying causes were presented. Hyponatremia patients were observed to be elderly, had more comorbidities, with severe pneumonic chest radiographic findings. They were also more likely to have a fever, nausea, higher leukocyte and neutrophils count, and a high sensitivity C-reactive protein (HS-CRP). Compared to normonatremia patients, renal insufficiency was common in both hyponatremia and hypernatremia patients. In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. The only significant differences between the hypernatremia and normonatremia patients were laboratory findings and clinical complications, and patients with hypernatremia were more likely to use traditional Chinese medicine for treatment compared to normonatremia patients. This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. CONCLUSION: Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality.
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spelling pubmed-75639042020-10-16 Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study Hu, Weihua lv, Xinke Li, Chang Xu, Yang Qi, Yiding Zhang, Zhuheng Li, Mingxuan Cai, Feina Liu, Dan Yue, Jiang Ye, Maoqing Chen, Qijian Shi, Kailei Intern Emerg Med Im - Original BACKGROUND: The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. METHODS AND RESULTS: A total of 1,254 COVID-19 patients comprising 124 (9.9%) hyponatremic patients (under 135 mmol/L) and 30 (2.4%) hypernatremic patients (over 145 mmol/L) from three hospitals in Hubei, China, were enrolled in the study. The relationships between sodium balance disorders in COVID-19 patients, its clinical features, implications, and the underlying causes were presented. Hyponatremia patients were observed to be elderly, had more comorbidities, with severe pneumonic chest radiographic findings. They were also more likely to have a fever, nausea, higher leukocyte and neutrophils count, and a high sensitivity C-reactive protein (HS-CRP). Compared to normonatremia patients, renal insufficiency was common in both hyponatremia and hypernatremia patients. In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. The only significant differences between the hypernatremia and normonatremia patients were laboratory findings and clinical complications, and patients with hypernatremia were more likely to use traditional Chinese medicine for treatment compared to normonatremia patients. This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. CONCLUSION: Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality. Springer International Publishing 2020-10-16 2021 /pmc/articles/PMC7563904/ /pubmed/33064253 http://dx.doi.org/10.1007/s11739-020-02515-9 Text en © Società Italiana di Medicina Interna (SIMI) 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Im - Original
Hu, Weihua
lv, Xinke
Li, Chang
Xu, Yang
Qi, Yiding
Zhang, Zhuheng
Li, Mingxuan
Cai, Feina
Liu, Dan
Yue, Jiang
Ye, Maoqing
Chen, Qijian
Shi, Kailei
Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title_full Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title_fullStr Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title_full_unstemmed Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title_short Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study
title_sort disorders of sodium balance and its clinical implications in covid-19 patients: a multicenter retrospective study
topic Im - Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563904/
https://www.ncbi.nlm.nih.gov/pubmed/33064253
http://dx.doi.org/10.1007/s11739-020-02515-9
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