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First small-molecule PROTACs for G protein-coupled receptors: inducing α(1A)-adrenergic receptor degradation
Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the target protein level by the ubiquitin-proteasome pa...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563999/ https://www.ncbi.nlm.nih.gov/pubmed/33088687 http://dx.doi.org/10.1016/j.apsb.2020.01.014 |