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Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications

The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial nega...

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Autores principales: Baicry, Florent, Le Borgne, Pierrick, Fabacher, Thibaut, Behr, Martin, Lemaitre, Elena Laura, Gayol, Paul-Albert, Harscoat, Sébastien, Issur, Nirvan, Garnier-Kepka, Sabrina, Ohana, Mickael, Bilbault, Pascal, Oberlin, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564057/
https://www.ncbi.nlm.nih.gov/pubmed/32962092
http://dx.doi.org/10.3390/jcm9093014
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author Baicry, Florent
Le Borgne, Pierrick
Fabacher, Thibaut
Behr, Martin
Lemaitre, Elena Laura
Gayol, Paul-Albert
Harscoat, Sébastien
Issur, Nirvan
Garnier-Kepka, Sabrina
Ohana, Mickael
Bilbault, Pascal
Oberlin, Mathieu
author_facet Baicry, Florent
Le Borgne, Pierrick
Fabacher, Thibaut
Behr, Martin
Lemaitre, Elena Laura
Gayol, Paul-Albert
Harscoat, Sébastien
Issur, Nirvan
Garnier-Kepka, Sabrina
Ohana, Mickael
Bilbault, Pascal
Oberlin, Mathieu
author_sort Baicry, Florent
collection PubMed
description The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial negative RT-PCR in the emergency department (ED) during the COVID-19 outbreak. This study included two cohorts of adult inpatients admitted into the ED. All patients who were suspected to be infected with SARS-CoV-2 and who underwent a typical chest CT imaging were included. Thus, we studied two distinct cohorts: patients with positive RT-PCR (PCR+) and those with negative initial RT-PCR (PCR–). The data were analyzed using Bayesian methods. We included 66 patients in the PCR– group and 198 in the PCR+ group. The baseline characteristics did not differ except in terms of a proportion of lower chronic respiratory disease in the PCR– group. We noted a less severe clinical presentation in the PCR– group (lower respiratory rate, lower oxygen need and mechanical ventilation requirement). Hospital mortality (9.1% vs. 9.6%) did not differ between the two groups. Despite an initially less serious clinical presentation, the mortality of patients infected by SARS-CoV-2 with a negative RT-PCR did not differ from those with positive RT-PCR.
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spelling pubmed-75640572020-10-27 Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications Baicry, Florent Le Borgne, Pierrick Fabacher, Thibaut Behr, Martin Lemaitre, Elena Laura Gayol, Paul-Albert Harscoat, Sébastien Issur, Nirvan Garnier-Kepka, Sabrina Ohana, Mickael Bilbault, Pascal Oberlin, Mathieu J Clin Med Article The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial negative RT-PCR in the emergency department (ED) during the COVID-19 outbreak. This study included two cohorts of adult inpatients admitted into the ED. All patients who were suspected to be infected with SARS-CoV-2 and who underwent a typical chest CT imaging were included. Thus, we studied two distinct cohorts: patients with positive RT-PCR (PCR+) and those with negative initial RT-PCR (PCR–). The data were analyzed using Bayesian methods. We included 66 patients in the PCR– group and 198 in the PCR+ group. The baseline characteristics did not differ except in terms of a proportion of lower chronic respiratory disease in the PCR– group. We noted a less severe clinical presentation in the PCR– group (lower respiratory rate, lower oxygen need and mechanical ventilation requirement). Hospital mortality (9.1% vs. 9.6%) did not differ between the two groups. Despite an initially less serious clinical presentation, the mortality of patients infected by SARS-CoV-2 with a negative RT-PCR did not differ from those with positive RT-PCR. MDPI 2020-09-18 /pmc/articles/PMC7564057/ /pubmed/32962092 http://dx.doi.org/10.3390/jcm9093014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baicry, Florent
Le Borgne, Pierrick
Fabacher, Thibaut
Behr, Martin
Lemaitre, Elena Laura
Gayol, Paul-Albert
Harscoat, Sébastien
Issur, Nirvan
Garnier-Kepka, Sabrina
Ohana, Mickael
Bilbault, Pascal
Oberlin, Mathieu
Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title_full Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title_fullStr Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title_full_unstemmed Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title_short Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications
title_sort patients with initial negative rt-pcr and typical imaging of covid-19: clinical implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564057/
https://www.ncbi.nlm.nih.gov/pubmed/32962092
http://dx.doi.org/10.3390/jcm9093014
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