Cargando…

Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?

Persistent infections with the human pathogen Helicobacter pylori (H. pylori) have been closely associated with the induction and progression of a wide range of gastric disorders, including acute and chronic gastritis, ulceration in the stomach and duodenum, mucosa-associated lymphoid tissue (MALT)...

Descripción completa

Detalles Bibliográficos
Autores principales: Jarzab, Miroslaw, Posselt, Gernot, Meisner-Kober, Nicole, Wessler, Silja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564109/
https://www.ncbi.nlm.nih.gov/pubmed/32878302
http://dx.doi.org/10.3390/microorganisms8091328
_version_ 1783595638615703552
author Jarzab, Miroslaw
Posselt, Gernot
Meisner-Kober, Nicole
Wessler, Silja
author_facet Jarzab, Miroslaw
Posselt, Gernot
Meisner-Kober, Nicole
Wessler, Silja
author_sort Jarzab, Miroslaw
collection PubMed
description Persistent infections with the human pathogen Helicobacter pylori (H. pylori) have been closely associated with the induction and progression of a wide range of gastric disorders, including acute and chronic gastritis, ulceration in the stomach and duodenum, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. The pathogenesis of H. pylori is determined by a complicated network of manifold mechanisms of pathogen–host interactions, which involves a coordinated interplay of H. pylori pathogenicity and virulence factors with host cells. While these molecular and cellular mechanisms have been intensively investigated to date, the knowledge about outer membrane vesicles (OMVs) derived from H. pylori and their implication in bacterial pathogenesis is not well developed. In this review, we summarize the current knowledge on H. pylori-derived OMVs.
format Online
Article
Text
id pubmed-7564109
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75641092020-10-27 Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis? Jarzab, Miroslaw Posselt, Gernot Meisner-Kober, Nicole Wessler, Silja Microorganisms Review Persistent infections with the human pathogen Helicobacter pylori (H. pylori) have been closely associated with the induction and progression of a wide range of gastric disorders, including acute and chronic gastritis, ulceration in the stomach and duodenum, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. The pathogenesis of H. pylori is determined by a complicated network of manifold mechanisms of pathogen–host interactions, which involves a coordinated interplay of H. pylori pathogenicity and virulence factors with host cells. While these molecular and cellular mechanisms have been intensively investigated to date, the knowledge about outer membrane vesicles (OMVs) derived from H. pylori and their implication in bacterial pathogenesis is not well developed. In this review, we summarize the current knowledge on H. pylori-derived OMVs. MDPI 2020-08-31 /pmc/articles/PMC7564109/ /pubmed/32878302 http://dx.doi.org/10.3390/microorganisms8091328 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jarzab, Miroslaw
Posselt, Gernot
Meisner-Kober, Nicole
Wessler, Silja
Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title_full Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title_fullStr Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title_full_unstemmed Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title_short Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
title_sort helicobacter pylori-derived outer membrane vesicles (omvs): role in bacterial pathogenesis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564109/
https://www.ncbi.nlm.nih.gov/pubmed/32878302
http://dx.doi.org/10.3390/microorganisms8091328
work_keys_str_mv AT jarzabmiroslaw helicobacterpyloriderivedoutermembranevesiclesomvsroleinbacterialpathogenesis
AT posseltgernot helicobacterpyloriderivedoutermembranevesiclesomvsroleinbacterialpathogenesis
AT meisnerkobernicole helicobacterpyloriderivedoutermembranevesiclesomvsroleinbacterialpathogenesis
AT wesslersilja helicobacterpyloriderivedoutermembranevesiclesomvsroleinbacterialpathogenesis