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Special Issue: Animal Modeling in Cancer
Recent advances in high-throughput sequencing techniques have significantly accelerated the development of personalized diagnostic tools and cancer treatments. However, a comparative analysis of experimental animals that share similar genetic, physiological, and behavioral traits with humans remains...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564229/ https://www.ncbi.nlm.nih.gov/pubmed/32867303 http://dx.doi.org/10.3390/genes11091009 |
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author | Korinek, Vladimir |
author_facet | Korinek, Vladimir |
author_sort | Korinek, Vladimir |
collection | PubMed |
description | Recent advances in high-throughput sequencing techniques have significantly accelerated the development of personalized diagnostic tools and cancer treatments. However, a comparative analysis of experimental animals that share similar genetic, physiological, and behavioral traits with humans remains the basis for understanding the pathological mechanisms associated with human diseases, including cancer. The generation and characterization of suitable animal models mimicking tumor growth and progression thus represents an important “component” of tumor biology research. The presented Special Issue contains ten review articles, which, based on data obtained from various animal models, summarize a number of aspects of the tumor formation process that include gastrointestinal neoplasia, breast cancer, hematological malignancies, melanoma, and brain tumors. This Special Issue nicely illustrates how the study of suitable living models uncovers not only the fundamental molecular and cellular bases of neoplastic growth, but might also indicate approaches to efficient cancer treatments. |
format | Online Article Text |
id | pubmed-7564229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75642292020-10-26 Special Issue: Animal Modeling in Cancer Korinek, Vladimir Genes (Basel) Editorial Recent advances in high-throughput sequencing techniques have significantly accelerated the development of personalized diagnostic tools and cancer treatments. However, a comparative analysis of experimental animals that share similar genetic, physiological, and behavioral traits with humans remains the basis for understanding the pathological mechanisms associated with human diseases, including cancer. The generation and characterization of suitable animal models mimicking tumor growth and progression thus represents an important “component” of tumor biology research. The presented Special Issue contains ten review articles, which, based on data obtained from various animal models, summarize a number of aspects of the tumor formation process that include gastrointestinal neoplasia, breast cancer, hematological malignancies, melanoma, and brain tumors. This Special Issue nicely illustrates how the study of suitable living models uncovers not only the fundamental molecular and cellular bases of neoplastic growth, but might also indicate approaches to efficient cancer treatments. MDPI 2020-08-27 /pmc/articles/PMC7564229/ /pubmed/32867303 http://dx.doi.org/10.3390/genes11091009 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Korinek, Vladimir Special Issue: Animal Modeling in Cancer |
title | Special Issue: Animal Modeling in Cancer |
title_full | Special Issue: Animal Modeling in Cancer |
title_fullStr | Special Issue: Animal Modeling in Cancer |
title_full_unstemmed | Special Issue: Animal Modeling in Cancer |
title_short | Special Issue: Animal Modeling in Cancer |
title_sort | special issue: animal modeling in cancer |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564229/ https://www.ncbi.nlm.nih.gov/pubmed/32867303 http://dx.doi.org/10.3390/genes11091009 |
work_keys_str_mv | AT korinekvladimir specialissueanimalmodelingincancer |