Cargando…

Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing

Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where convention...

Descripción completa

Detalles Bibliográficos
Autores principales: Augustin, Yolanda, Staines, Henry M., Krishna, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564301/
https://www.ncbi.nlm.nih.gov/pubmed/33075360
http://dx.doi.org/10.1016/j.pharmthera.2020.107706
_version_ 1783595683017654272
author Augustin, Yolanda
Staines, Henry M.
Krishna, Sanjeev
author_facet Augustin, Yolanda
Staines, Henry M.
Krishna, Sanjeev
author_sort Augustin, Yolanda
collection PubMed
description Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by financial cost. Drug repurposing can significantly shorten new therapeutic discovery pathways, ensuring greater accessibility and affordability globally. Artemisinins have an excellent safety and tolerability profile as well as being affordable for deployment in Low and Middle Class Income Countries at around USD1 per daily dose. Robust, well designed clinical trials of artemisinin drug repurposing are indicated for a variety of different cancers and treatment settings.
format Online
Article
Text
id pubmed-7564301
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-75643012020-10-16 Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing Augustin, Yolanda Staines, Henry M. Krishna, Sanjeev Pharmacol Ther Article Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by financial cost. Drug repurposing can significantly shorten new therapeutic discovery pathways, ensuring greater accessibility and affordability globally. Artemisinins have an excellent safety and tolerability profile as well as being affordable for deployment in Low and Middle Class Income Countries at around USD1 per daily dose. Robust, well designed clinical trials of artemisinin drug repurposing are indicated for a variety of different cancers and treatment settings. Published by Elsevier Inc. 2020-12 2020-10-16 /pmc/articles/PMC7564301/ /pubmed/33075360 http://dx.doi.org/10.1016/j.pharmthera.2020.107706 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Augustin, Yolanda
Staines, Henry M.
Krishna, Sanjeev
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title_full Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title_fullStr Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title_full_unstemmed Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title_short Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
title_sort artemisinins as a novel anti-cancer therapy: targeting a global cancer pandemic through drug repurposing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564301/
https://www.ncbi.nlm.nih.gov/pubmed/33075360
http://dx.doi.org/10.1016/j.pharmthera.2020.107706
work_keys_str_mv AT augustinyolanda artemisininsasanovelanticancertherapytargetingaglobalcancerpandemicthroughdrugrepurposing
AT staineshenrym artemisininsasanovelanticancertherapytargetingaglobalcancerpandemicthroughdrugrepurposing
AT krishnasanjeev artemisininsasanovelanticancertherapytargetingaglobalcancerpandemicthroughdrugrepurposing