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Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where convention...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564301/ https://www.ncbi.nlm.nih.gov/pubmed/33075360 http://dx.doi.org/10.1016/j.pharmthera.2020.107706 |
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author | Augustin, Yolanda Staines, Henry M. Krishna, Sanjeev |
author_facet | Augustin, Yolanda Staines, Henry M. Krishna, Sanjeev |
author_sort | Augustin, Yolanda |
collection | PubMed |
description | Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by financial cost. Drug repurposing can significantly shorten new therapeutic discovery pathways, ensuring greater accessibility and affordability globally. Artemisinins have an excellent safety and tolerability profile as well as being affordable for deployment in Low and Middle Class Income Countries at around USD1 per daily dose. Robust, well designed clinical trials of artemisinin drug repurposing are indicated for a variety of different cancers and treatment settings. |
format | Online Article Text |
id | pubmed-7564301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75643012020-10-16 Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing Augustin, Yolanda Staines, Henry M. Krishna, Sanjeev Pharmacol Ther Article Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by financial cost. Drug repurposing can significantly shorten new therapeutic discovery pathways, ensuring greater accessibility and affordability globally. Artemisinins have an excellent safety and tolerability profile as well as being affordable for deployment in Low and Middle Class Income Countries at around USD1 per daily dose. Robust, well designed clinical trials of artemisinin drug repurposing are indicated for a variety of different cancers and treatment settings. Published by Elsevier Inc. 2020-12 2020-10-16 /pmc/articles/PMC7564301/ /pubmed/33075360 http://dx.doi.org/10.1016/j.pharmthera.2020.107706 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Augustin, Yolanda Staines, Henry M. Krishna, Sanjeev Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title | Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title_full | Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title_fullStr | Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title_full_unstemmed | Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title_short | Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing |
title_sort | artemisinins as a novel anti-cancer therapy: targeting a global cancer pandemic through drug repurposing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564301/ https://www.ncbi.nlm.nih.gov/pubmed/33075360 http://dx.doi.org/10.1016/j.pharmthera.2020.107706 |
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