Cargando…

Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions

BACKGROUND: Smoking is one of the greatest threats to public health worldwide. We integrated phenome-wide association study (PheWAS) and Mendelian randomization (MR) approaches to explore causal effects of genetically predicted smoking intensity across the human disease spectrum. METHODS: We conduct...

Descripción completa

Detalles Bibliográficos
Autores principales:	King, Catherine, Mulugeta, Anwar, Nabi, Farhana, Walton, Robert, Zhou, Ang, Hyppönen, Elina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564324/ https://www.ncbi.nlm.nih.gov/pubmed/33089118 http://dx.doi.org/10.1016/j.eclinm.2020.100488

Ejemplares similares

A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank
por: Leppert, Beate, et al.
Publicado: (2020)

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank
por: Li, Xue, et al.
Publicado: (2018)

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank
por: Zhang, Xiaomeng, et al.
Publicado: (2021)

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View
por: Pendergrass, Sarah A, et al.
Publicado: (2012)

MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization
por: Millard, Louise A. C., et al.
Publicado: (2015)

Realising the full potential of MR-PHeWAS in cancer
por: Bowden, Jack
Publicado: (2020)

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent
por: Li, Longman, et al.
Publicado: (2021)

Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data
por: Nam, Yonghyun, et al.
Publicado: (2022)

Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank
por: Lumsden, Amanda L., et al.
Publicado: (2020)

BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data
por: Kässens, Jan Christian, et al.
Publicado: (2021)

Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study
por: Mulugeta, Anwar, et al.
Publicado: (2020)

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging
por: Millard, Louise A. C., et al.
Publicado: (2019)

Learning Opportunities for Drug Repositioning via GWAS and PheWAS Findings
por: Yin, Wen, et al.
Publicado: (2018)

netCRS: Network-based comorbidity risk score for prediction of myocardial infarction using biobank-scaled PheWAS data
por: Nam, Yonghyun, et al.
Publicado: (2022)

Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank
por: Mulugeta, Anwar, et al.
Publicado: (2022)

Connecting phenotype to genotype: PheWAS-inspired analysis of autism spectrum disorder
por: Matta, John, et al.
Publicado: (2022)

PheWAS-Based Systems Genetics Methods for Anti-Breast Cancer Drug Discovery
por: Gao, Min, et al.
Publicado: (2019)

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort
por: Read, Robert W., et al.
Publicado: (2019)

Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach
por: Feng, Yen-Chen A., et al.
Publicado: (2022)

Healthy Lifestyle, Genetic Risk and Brain Health: A Gene-Environment Interaction Study in the UK Biobank
por: Mulugeta, Anwar, et al.
Publicado: (2022)

Vitamin D and brain health: an observational and Mendelian randomization study
por: Navale, Shreeya S, et al.
Publicado: (2022)

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations
por: Denny, Joshua C., et al.
Publicado: (2010)

Human-Disease Phenotype Map Derived from PheWAS across 38,682 Individuals
por: Verma, Anurag, et al.
Publicado: (2019)

Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology
por: Ahmed, Muktar, et al.
Publicado: (2022)

Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors
por: Hellwege, Jacklyn N., et al.
Publicado: (2023)

Educational inequality in multimorbidity: causality and causal pathways. A mendelian randomisation study in UK Biobank
por: North, Teri-Louise, et al.
Publicado: (2023)

A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
por: Zhao, Xueyan, et al.
Publicado: (2019)

Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
por: Khosravi, Ali, et al.
Publicado: (2019)

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016)

A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations
por: Kim, Seung-Soo, et al.
Publicado: (2021)

A Case-Crossover Phenome-wide association study (PheWAS) for understanding Post-COVID-19 diagnosis patterns
por: Haupert, Spencer R., et al.
Publicado: (2022)

A phenome-wide association study (PheWAS) to identify the health impacts of 4-cresol sulfate in the Nagahama Study
por: Ou, Huiting, et al.
Publicado: (2023)

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
por: Pendergrass, Sarah A., et al.
Publicado: (2013)

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders
por: Topaloudi, Apostolia, et al.
Publicado: (2023)

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank
por: Funck‐Brentano, Thomas, et al.
Publicado: (2019)

Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
por: Zhou, Ang, et al.
Publicado: (2022)

Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
por: Vimaleswaran, Karani Santhanakrishnan, et al.
Publicado: (2021)

Multi-PheWAS intersection approach to identify sex differences across comorbidities in 59 140 pediatric patients with autism spectrum disorder
por: Gutiérrez-Sacristán, Alba, et al.
Publicado: (2021)

The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank
por: Harrison, Sean, et al.
Publicado: (2020)

No causal association between plasma cystatin C and cardiovascular diseases: Mendelian randomization analyses in UK biobank
por: Tu, Jingjing, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pn7pjo9bron8ktit9vp1o4o7u9