A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling

The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodegeneration of specific neuronal subtypes. The cholinergic system, characterized by its use of the neurotransmitter acetylcholine, is one of the first to degenerate in Alzhe...

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Detalles Bibliográficos
Autores principales: Muñoz, Sonia Sanz, Engel, Martin, Balez, Rachelle, Do-Ha, Dzung, Cabral-da-Silva, Mauricio Castro, Hernández, Damian, Berg, Tracey, Fifita, Jennifer A., Grima, Natalie, Yang, Shu, Blair, Ian P., Nicholson, Garth, Cook, Anthony L., Hewitt, Alex W., Pébay, Alice, Ooi, Lezanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564334/
https://www.ncbi.nlm.nih.gov/pubmed/32887382
http://dx.doi.org/10.3390/cells9092018

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