Cargando…
L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs
SIMPLE SUMMARY: Nitric oxide and arginine metabolism in colorectal cancer (CRC) holds potential for therapeutic intervention. We hypothesized that it can be modulated by oxicams, a class of non-steroidal anti-inflammatory drugs with documented chemopreventive and antineoplastic activity. The aim of...
Autores principales: | Krzystek-Korpacka, Małgorzata, Szczęśniak-Sięga, Berenika, Szczuka, Izabela, Fortuna, Paulina, Zawadzki, Marek, Kubiak, Agnieszka, Mierzchała-Pasierb, Magdalena, Fleszar, Mariusz G., Lewandowski, Łukasz, Serek, Paweł, Jamrozik, Natalia, Neubauer, Katarzyna, Wiśniewski, Jerzy, Kempiński, Radosław, Witkiewicz, Wojciech, Bednarz-Misa, Iwona |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564351/ https://www.ncbi.nlm.nih.gov/pubmed/32932854 http://dx.doi.org/10.3390/cancers12092594 |
Ejemplares similares
-
Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer
por: Lewandowska, Paulina, et al.
Publicado: (2021) -
Heat Shock Proteins HSPA1 and HSP90AA1 Are Upregulated in Colorectal Polyps and Can Be Targeted in Cancer Cells by Anti-Inflammatory Oxicams with Arylpiperazine Pharmacophore and Benzoyl Moiety Substitutions at Thiazine Ring
por: Szczuka, Izabela, et al.
Publicado: (2021) -
Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers
por: Bednarz-Misa, Iwona, et al.
Publicado: (2021) -
Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings
por: Krzystek-Korpacka, Małgorzata, et al.
Publicado: (2020) -
L-Arginine/NO Pathway Metabolites in Colorectal Cancer: Relevance as Disease Biomarkers and Predictors of Adverse Clinical Outcomes Following Surgery
por: Bednarz-Misa, Iwona, et al.
Publicado: (2020)