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Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients

Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and is known to play a significant role in the development of atherosclerosis. In this study, we sought to inves...

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Autores principales: Zamzam, Abdelrahman, Syed, Muzammil H., Greco, Elisa, Wheatcroft, Mark, Jain, Shubha, Khan, Hamzah, Singh, Krishna K., Forbes, Thomas L., Rotstein, Ori, Abdin, Rawand, Qadura, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564356/
https://www.ncbi.nlm.nih.gov/pubmed/32887447
http://dx.doi.org/10.3390/jcm9092843
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author Zamzam, Abdelrahman
Syed, Muzammil H.
Greco, Elisa
Wheatcroft, Mark
Jain, Shubha
Khan, Hamzah
Singh, Krishna K.
Forbes, Thomas L.
Rotstein, Ori
Abdin, Rawand
Qadura, Mohammad
author_facet Zamzam, Abdelrahman
Syed, Muzammil H.
Greco, Elisa
Wheatcroft, Mark
Jain, Shubha
Khan, Hamzah
Singh, Krishna K.
Forbes, Thomas L.
Rotstein, Ori
Abdin, Rawand
Qadura, Mohammad
author_sort Zamzam, Abdelrahman
collection PubMed
description Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and is known to play a significant role in the development of atherosclerosis. In this study, we sought to investigate whether FABP4 is associated with PAD in patients with type 2 diabetes mellitus (DM). FABP4 plasma levels were studied in 119 diabetic patients with PAD (DM-PAD) and 49 diabetic patients without PAD (DM-noPAD) presenting to St. Michael’s Hospital between October 2017 and September 2018. Levels of FABP4 in DM-PAD patients (23.34 ± 15.27 ng/mL) were found to be over two-fold higher than the levels in DM-noPAD patients (10.3 ± 7.59 ng/mL). Regression analysis demonstrated a significant association between FABP4 levels and DM-PAD after adjusting for age, sex, prior history of coronary arterial disease and white blood cells count (OR, 2.77; 95% CI, 1.81–4.31; p-value = 0.001). Relative to DM-noPAD controls, plasma FABP4 levels in DM-PAD patients were noted to be inversely correlated with the ankle brachial index (ABI; r= −0.374, p-value < 0.001). The diagnostic ability of FABP4 was investigated using receiver operator curves (ROC) and area under the curve (AUC) analysis. FABP4 had an AUC of 0.79, which improved to 0.86 after adjusting for age, sex and prior history of coronary arterial disease. This raises a possibility of utilizing FABP4 as a biomarker for diagnosing PAD in diabetic patients.
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spelling pubmed-75643562020-10-26 Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients Zamzam, Abdelrahman Syed, Muzammil H. Greco, Elisa Wheatcroft, Mark Jain, Shubha Khan, Hamzah Singh, Krishna K. Forbes, Thomas L. Rotstein, Ori Abdin, Rawand Qadura, Mohammad J Clin Med Article Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and is known to play a significant role in the development of atherosclerosis. In this study, we sought to investigate whether FABP4 is associated with PAD in patients with type 2 diabetes mellitus (DM). FABP4 plasma levels were studied in 119 diabetic patients with PAD (DM-PAD) and 49 diabetic patients without PAD (DM-noPAD) presenting to St. Michael’s Hospital between October 2017 and September 2018. Levels of FABP4 in DM-PAD patients (23.34 ± 15.27 ng/mL) were found to be over two-fold higher than the levels in DM-noPAD patients (10.3 ± 7.59 ng/mL). Regression analysis demonstrated a significant association between FABP4 levels and DM-PAD after adjusting for age, sex, prior history of coronary arterial disease and white blood cells count (OR, 2.77; 95% CI, 1.81–4.31; p-value = 0.001). Relative to DM-noPAD controls, plasma FABP4 levels in DM-PAD patients were noted to be inversely correlated with the ankle brachial index (ABI; r= −0.374, p-value < 0.001). The diagnostic ability of FABP4 was investigated using receiver operator curves (ROC) and area under the curve (AUC) analysis. FABP4 had an AUC of 0.79, which improved to 0.86 after adjusting for age, sex and prior history of coronary arterial disease. This raises a possibility of utilizing FABP4 as a biomarker for diagnosing PAD in diabetic patients. MDPI 2020-09-02 /pmc/articles/PMC7564356/ /pubmed/32887447 http://dx.doi.org/10.3390/jcm9092843 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zamzam, Abdelrahman
Syed, Muzammil H.
Greco, Elisa
Wheatcroft, Mark
Jain, Shubha
Khan, Hamzah
Singh, Krishna K.
Forbes, Thomas L.
Rotstein, Ori
Abdin, Rawand
Qadura, Mohammad
Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title_full Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title_fullStr Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title_full_unstemmed Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title_short Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
title_sort fatty acid binding protein 4—a circulating protein associated with peripheral arterial disease in diabetic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564356/
https://www.ncbi.nlm.nih.gov/pubmed/32887447
http://dx.doi.org/10.3390/jcm9092843
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