Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells

Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immatu...

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Autores principales: Krumb, Matthias, Frey, Marie-Luise, Langhanki, Jens, Forster, Robert, Kowalczyk, Danuta, Mailänder, Volker, Landfester, Katharina, Opatz, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564404/
https://www.ncbi.nlm.nih.gov/pubmed/32932639
http://dx.doi.org/10.3390/cells9092087
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author Krumb, Matthias
Frey, Marie-Luise
Langhanki, Jens
Forster, Robert
Kowalczyk, Danuta
Mailänder, Volker
Landfester, Katharina
Opatz, Till
author_facet Krumb, Matthias
Frey, Marie-Luise
Langhanki, Jens
Forster, Robert
Kowalczyk, Danuta
Mailänder, Volker
Landfester, Katharina
Opatz, Till
author_sort Krumb, Matthias
collection PubMed
description Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.
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spelling pubmed-75644042020-10-26 Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells Krumb, Matthias Frey, Marie-Luise Langhanki, Jens Forster, Robert Kowalczyk, Danuta Mailänder, Volker Landfester, Katharina Opatz, Till Cells Article Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. MDPI 2020-09-12 /pmc/articles/PMC7564404/ /pubmed/32932639 http://dx.doi.org/10.3390/cells9092087 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krumb, Matthias
Frey, Marie-Luise
Langhanki, Jens
Forster, Robert
Kowalczyk, Danuta
Mailänder, Volker
Landfester, Katharina
Opatz, Till
Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title_full Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title_fullStr Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title_full_unstemmed Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title_short Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
title_sort multivalency beats complexity: a study on the cell uptake of carbohydrate functionalized nanocarriers to dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564404/
https://www.ncbi.nlm.nih.gov/pubmed/32932639
http://dx.doi.org/10.3390/cells9092087
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