Cargando…
Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma
Background: Recent studies have demonstrated that the tumor microenvironment, known to be influenced by inflammatory cells, plays a crucial role in cancer progression and clinical outcome of patients. The objective of the present study was to investigate prognostic values of preoperative neutrophil-...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564429/ https://www.ncbi.nlm.nih.gov/pubmed/32911724 http://dx.doi.org/10.3390/jcm9092898 |
_version_ | 1783595712765755392 |
---|---|
author | Jeong, Min Jin Park, Jung Hyun Hur, Soo Young Kim, Chan Joo Nam, Hae Seong Lee, Yong Seok |
author_facet | Jeong, Min Jin Park, Jung Hyun Hur, Soo Young Kim, Chan Joo Nam, Hae Seong Lee, Yong Seok |
author_sort | Jeong, Min Jin |
collection | PubMed |
description | Background: Recent studies have demonstrated that the tumor microenvironment, known to be influenced by inflammatory cells, plays a crucial role in cancer progression and clinical outcome of patients. The objective of the present study was to investigate prognostic values of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for disease-free survival (DFS) and overall survival (OS) of uterine sarcoma patients. Methods: Ninety-nine patients with uterine sarcoma treated in eight multicenter institutions over the last 20 years were retrospectively analyzed. Curves of DFS and OS were calculated using the Kaplan–Meier method, and univariate and multivariate analyses of various prognostic factors were performed using a Cox proportional hazard regression model. Results: High NLR was significantly associated with worse DFS (p = 0.007) and OS (p = 0.039). Advanced stage (p = 0.017) and high mitotic index (p = 0.036) retained their prognostic significance for DFS. Other clinical variables, including PLR, CA125, and lactate dehydrogenase (LDH) failed to show significant impact. Conclusions: Our findings showed that an elevated preoperative NLR was associated with poor clinical outcome in uterine sarcoma patients. Our results suggest that high NLR in early-stage uterine sarcoma patients might indicate that such patients need more intensive treatments. |
format | Online Article Text |
id | pubmed-7564429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75644292020-10-26 Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma Jeong, Min Jin Park, Jung Hyun Hur, Soo Young Kim, Chan Joo Nam, Hae Seong Lee, Yong Seok J Clin Med Article Background: Recent studies have demonstrated that the tumor microenvironment, known to be influenced by inflammatory cells, plays a crucial role in cancer progression and clinical outcome of patients. The objective of the present study was to investigate prognostic values of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for disease-free survival (DFS) and overall survival (OS) of uterine sarcoma patients. Methods: Ninety-nine patients with uterine sarcoma treated in eight multicenter institutions over the last 20 years were retrospectively analyzed. Curves of DFS and OS were calculated using the Kaplan–Meier method, and univariate and multivariate analyses of various prognostic factors were performed using a Cox proportional hazard regression model. Results: High NLR was significantly associated with worse DFS (p = 0.007) and OS (p = 0.039). Advanced stage (p = 0.017) and high mitotic index (p = 0.036) retained their prognostic significance for DFS. Other clinical variables, including PLR, CA125, and lactate dehydrogenase (LDH) failed to show significant impact. Conclusions: Our findings showed that an elevated preoperative NLR was associated with poor clinical outcome in uterine sarcoma patients. Our results suggest that high NLR in early-stage uterine sarcoma patients might indicate that such patients need more intensive treatments. MDPI 2020-09-08 /pmc/articles/PMC7564429/ /pubmed/32911724 http://dx.doi.org/10.3390/jcm9092898 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jeong, Min Jin Park, Jung Hyun Hur, Soo Young Kim, Chan Joo Nam, Hae Seong Lee, Yong Seok Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title | Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title_full | Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title_fullStr | Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title_full_unstemmed | Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title_short | Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma |
title_sort | preoperative neutrophil-to-lymphocyte ratio as a prognostic factor in uterine sarcoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564429/ https://www.ncbi.nlm.nih.gov/pubmed/32911724 http://dx.doi.org/10.3390/jcm9092898 |
work_keys_str_mv | AT jeongminjin preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma AT parkjunghyun preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma AT hursooyoung preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma AT kimchanjoo preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma AT namhaeseong preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma AT leeyongseok preoperativeneutrophiltolymphocyteratioasaprognosticfactorinuterinesarcoma |