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Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?

Coronavirus disease 2019 (COVID-19) patients can develop interstitial pneumonia, which, in turn, can evolve into acute respiratory distress syndrome (ARDS). This is accompanied by an inflammatory cytokine storm. severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has proteins capable o...

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Autores principales: Falcone, Carmela, Caracciolo, Massimo, Correale, Pierpaolo, Macheda, Sebastiano, Vadalà, Eugenio Giuseppe, La Scala, Stefano, Tescione, Marco, Danieli, Roberta, Ferrarelli, Anna, Tarsitano, Maria Grazia, Romano, Lorenzo, De Lorenzo, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564484/
https://www.ncbi.nlm.nih.gov/pubmed/32967358
http://dx.doi.org/10.3390/jcm9093045
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author Falcone, Carmela
Caracciolo, Massimo
Correale, Pierpaolo
Macheda, Sebastiano
Vadalà, Eugenio Giuseppe
La Scala, Stefano
Tescione, Marco
Danieli, Roberta
Ferrarelli, Anna
Tarsitano, Maria Grazia
Romano, Lorenzo
De Lorenzo, Antonino
author_facet Falcone, Carmela
Caracciolo, Massimo
Correale, Pierpaolo
Macheda, Sebastiano
Vadalà, Eugenio Giuseppe
La Scala, Stefano
Tescione, Marco
Danieli, Roberta
Ferrarelli, Anna
Tarsitano, Maria Grazia
Romano, Lorenzo
De Lorenzo, Antonino
author_sort Falcone, Carmela
collection PubMed
description Coronavirus disease 2019 (COVID-19) patients can develop interstitial pneumonia, which, in turn, can evolve into acute respiratory distress syndrome (ARDS). This is accompanied by an inflammatory cytokine storm. severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has proteins capable of promoting the cytokine storm, especially in patients with comorbidities, including obesity. Since currently no resolutive therapy for ARDS has been found and given the scientific literature regarding the use of adenosine, its application has been hypothesized. Through its receptors, adenosine is able to inhibit the acute inflammatory process, increase the protection capacity of the epithelial barrier, and reduce the damage due to an overactivation of the immune system, such as that occurring in cytokine storms. These features are known in ischemia/reperfusion models and could also be exploited in acute lung injury with hypoxia. Considering these hypotheses, a COVID-19 patient with unresponsive respiratory failure was treated with adenosine for compassionate use. The results showed a rapid improvement of clinical conditions, with negativity of SARS-CoV2 detection.
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spelling pubmed-75644842020-10-26 Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome? Falcone, Carmela Caracciolo, Massimo Correale, Pierpaolo Macheda, Sebastiano Vadalà, Eugenio Giuseppe La Scala, Stefano Tescione, Marco Danieli, Roberta Ferrarelli, Anna Tarsitano, Maria Grazia Romano, Lorenzo De Lorenzo, Antonino J Clin Med Review Coronavirus disease 2019 (COVID-19) patients can develop interstitial pneumonia, which, in turn, can evolve into acute respiratory distress syndrome (ARDS). This is accompanied by an inflammatory cytokine storm. severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has proteins capable of promoting the cytokine storm, especially in patients with comorbidities, including obesity. Since currently no resolutive therapy for ARDS has been found and given the scientific literature regarding the use of adenosine, its application has been hypothesized. Through its receptors, adenosine is able to inhibit the acute inflammatory process, increase the protection capacity of the epithelial barrier, and reduce the damage due to an overactivation of the immune system, such as that occurring in cytokine storms. These features are known in ischemia/reperfusion models and could also be exploited in acute lung injury with hypoxia. Considering these hypotheses, a COVID-19 patient with unresponsive respiratory failure was treated with adenosine for compassionate use. The results showed a rapid improvement of clinical conditions, with negativity of SARS-CoV2 detection. MDPI 2020-09-21 /pmc/articles/PMC7564484/ /pubmed/32967358 http://dx.doi.org/10.3390/jcm9093045 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Falcone, Carmela
Caracciolo, Massimo
Correale, Pierpaolo
Macheda, Sebastiano
Vadalà, Eugenio Giuseppe
La Scala, Stefano
Tescione, Marco
Danieli, Roberta
Ferrarelli, Anna
Tarsitano, Maria Grazia
Romano, Lorenzo
De Lorenzo, Antonino
Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title_full Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title_fullStr Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title_full_unstemmed Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title_short Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?
title_sort can adenosine fight covid-19 acute respiratory distress syndrome?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564484/
https://www.ncbi.nlm.nih.gov/pubmed/32967358
http://dx.doi.org/10.3390/jcm9093045
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