Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma

SIMPLE SUMMARY: Medulloblastoma is the most common malignant brain tumor in children. In a subset of cases, a causal factor is a constitutive mutation of the TP53 gene, which may be inherited or arise for the first time in a patient (de novo). Using an immunohistochemistry assay as a screening tool,...

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Detalles Bibliográficos
Autores principales: Azzollini, Jacopo, Schiavello, Elisabetta, Buttarelli, Francesca Romana, Clerici, Carlo Alfredo, Tizzoni, Laura, Vecchi, Giovanna De, Capra, Fabio, Pisati, Federica, Biassoni, Veronica, Runza, Letterio, Carrabba, Giorgio, Giangaspero, Felice, Massimino, Maura, Pensotti, Valeria, Manoukian, Siranoush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564492/
https://www.ncbi.nlm.nih.gov/pubmed/32899294
http://dx.doi.org/10.3390/cancers12092503

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