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Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

Diabetes mellitus (DM) is a common disease worldwide. There is a strong association between DM and neurovascular and neurodegenerative disorders. The first group mainly consists of diabetic retinopathy, diabetic neuropathy and stroke, whereas, the second group includes Alzheimer’s disease, Parkinson...

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Autores principales: Gasecka, Aleksandra, Siwik, Dominika, Gajewska, Magdalena, Jaguszewski, Miłosz J., Mazurek, Tomasz, Filipiak, Krzysztof J., Postuła, Marek, Eyileten, Ceren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564566/
https://www.ncbi.nlm.nih.gov/pubmed/32872672
http://dx.doi.org/10.3390/jcm9092807
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author Gasecka, Aleksandra
Siwik, Dominika
Gajewska, Magdalena
Jaguszewski, Miłosz J.
Mazurek, Tomasz
Filipiak, Krzysztof J.
Postuła, Marek
Eyileten, Ceren
author_facet Gasecka, Aleksandra
Siwik, Dominika
Gajewska, Magdalena
Jaguszewski, Miłosz J.
Mazurek, Tomasz
Filipiak, Krzysztof J.
Postuła, Marek
Eyileten, Ceren
author_sort Gasecka, Aleksandra
collection PubMed
description Diabetes mellitus (DM) is a common disease worldwide. There is a strong association between DM and neurovascular and neurodegenerative disorders. The first group mainly consists of diabetic retinopathy, diabetic neuropathy and stroke, whereas, the second group includes Alzheimer’s disease, Parkinson’s disease, mild cognitive impairment and dementia. The aforementioned diseases have a common pathophysiological background including insulin resistance, oxidative stress, atherosclerosis and vascular injury. The increasing prevalence of neurovascular and neurodegenerative disorders among diabetic patients has resulted in an urgent need to develop biomarkers for their prediction and/or early detection. The aim of this review is to present the potential application of the most promising biomarkers of diabetes-related neurodegenerative and neurovascular disorders, including amylin, β-amyloid, C-reactive protein (CRP), dopamine, gamma-glutamyl transferase (GGT), glycogen synthase kinase 3β, homocysteine, microRNAs (mi-RNAs), paraoxonase 1, phosphoinositide 3-kinases, tau protein and various growth factors. The most clinically promising biomarkers of neurovascular and neurodegenerative complications in DM are hsCRP, GGT, homocysteine and miRNAs. However, all biomarkers discussed in this review could become a part of the potential multi-biomarker screening panel for diabetic patients at risk of neurovascular and neurodegenerative complications.
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spelling pubmed-75645662020-10-29 Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes Gasecka, Aleksandra Siwik, Dominika Gajewska, Magdalena Jaguszewski, Miłosz J. Mazurek, Tomasz Filipiak, Krzysztof J. Postuła, Marek Eyileten, Ceren J Clin Med Review Diabetes mellitus (DM) is a common disease worldwide. There is a strong association between DM and neurovascular and neurodegenerative disorders. The first group mainly consists of diabetic retinopathy, diabetic neuropathy and stroke, whereas, the second group includes Alzheimer’s disease, Parkinson’s disease, mild cognitive impairment and dementia. The aforementioned diseases have a common pathophysiological background including insulin resistance, oxidative stress, atherosclerosis and vascular injury. The increasing prevalence of neurovascular and neurodegenerative disorders among diabetic patients has resulted in an urgent need to develop biomarkers for their prediction and/or early detection. The aim of this review is to present the potential application of the most promising biomarkers of diabetes-related neurodegenerative and neurovascular disorders, including amylin, β-amyloid, C-reactive protein (CRP), dopamine, gamma-glutamyl transferase (GGT), glycogen synthase kinase 3β, homocysteine, microRNAs (mi-RNAs), paraoxonase 1, phosphoinositide 3-kinases, tau protein and various growth factors. The most clinically promising biomarkers of neurovascular and neurodegenerative complications in DM are hsCRP, GGT, homocysteine and miRNAs. However, all biomarkers discussed in this review could become a part of the potential multi-biomarker screening panel for diabetic patients at risk of neurovascular and neurodegenerative complications. MDPI 2020-08-30 /pmc/articles/PMC7564566/ /pubmed/32872672 http://dx.doi.org/10.3390/jcm9092807 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gasecka, Aleksandra
Siwik, Dominika
Gajewska, Magdalena
Jaguszewski, Miłosz J.
Mazurek, Tomasz
Filipiak, Krzysztof J.
Postuła, Marek
Eyileten, Ceren
Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title_full Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title_fullStr Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title_full_unstemmed Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title_short Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
title_sort early biomarkers of neurodegenerative and neurovascular disorders in diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564566/
https://www.ncbi.nlm.nih.gov/pubmed/32872672
http://dx.doi.org/10.3390/jcm9092807
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