Cargando…
Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis
The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accorda...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564684/ https://www.ncbi.nlm.nih.gov/pubmed/32825458 http://dx.doi.org/10.3390/jcm9092698 |
_version_ | 1783595771623374848 |
---|---|
author | Váncsa, Szilárd Németh, Dávid Hegyi, Péter Szakács, Zsolt Hegyi, Péter Jeno Pécsi, Dániel Mikó, Alexandra Erőss, Bálint Erős, Adrienn Pár, Gabriella |
author_facet | Váncsa, Szilárd Németh, Dávid Hegyi, Péter Szakács, Zsolt Hegyi, Péter Jeno Pécsi, Dániel Mikó, Alexandra Erőss, Bálint Erős, Adrienn Pár, Gabriella |
author_sort | Váncsa, Szilárd |
collection | PubMed |
description | The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care. |
format | Online Article Text |
id | pubmed-7564684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75646842020-10-29 Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis Váncsa, Szilárd Németh, Dávid Hegyi, Péter Szakács, Zsolt Hegyi, Péter Jeno Pécsi, Dániel Mikó, Alexandra Erőss, Bálint Erős, Adrienn Pár, Gabriella J Clin Med Review The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care. MDPI 2020-08-20 /pmc/articles/PMC7564684/ /pubmed/32825458 http://dx.doi.org/10.3390/jcm9092698 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Váncsa, Szilárd Németh, Dávid Hegyi, Péter Szakács, Zsolt Hegyi, Péter Jeno Pécsi, Dániel Mikó, Alexandra Erőss, Bálint Erős, Adrienn Pár, Gabriella Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title | Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title_full | Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title_fullStr | Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title_short | Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis |
title_sort | fatty liver disease and non-alcoholic fatty liver disease worsen the outcome in acute pancreatitis: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564684/ https://www.ncbi.nlm.nih.gov/pubmed/32825458 http://dx.doi.org/10.3390/jcm9092698 |
work_keys_str_mv | AT vancsaszilard fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT nemethdavid fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT hegyipeter fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT szakacszsolt fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT hegyipeterjeno fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT pecsidaniel fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT mikoalexandra fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT erossbalint fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT erosadrienn fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis AT pargabriella fattyliverdiseaseandnonalcoholicfattyliverdiseaseworsentheoutcomeinacutepancreatitisasystematicreviewandmetaanalysis |