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Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients

The morbidity and mortality of severely injured patients are commonly affected by multiple factors. Especially, severe chest trauma has been shown to be a significant factor in considering outcome. Contemporaneously, weight-associated endocrinological, haematological, and metabolic deviations from t...

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Autores principales: Eckhardt, Thurid, Horst, Klemens, Störmann, Philipp, Bläsius, Felix, Hofman, Martijn, Herren, Christian, Kobbe, Philipp, Hildebrand, Frank, Andruszkow, Hagen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564760/
https://www.ncbi.nlm.nih.gov/pubmed/32858822
http://dx.doi.org/10.3390/jcm9092752
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author Eckhardt, Thurid
Horst, Klemens
Störmann, Philipp
Bläsius, Felix
Hofman, Martijn
Herren, Christian
Kobbe, Philipp
Hildebrand, Frank
Andruszkow, Hagen
author_facet Eckhardt, Thurid
Horst, Klemens
Störmann, Philipp
Bläsius, Felix
Hofman, Martijn
Herren, Christian
Kobbe, Philipp
Hildebrand, Frank
Andruszkow, Hagen
author_sort Eckhardt, Thurid
collection PubMed
description The morbidity and mortality of severely injured patients are commonly affected by multiple factors. Especially, severe chest trauma has been shown to be a significant factor in considering outcome. Contemporaneously, weight-associated endocrinological, haematological, and metabolic deviations from the norm seem to have an impact on the posttraumatic course. Therefore, the aim of this study was to determine the influence of body weight on severely injured patients by emphasizing chest trauma. A total of 338 severely injured patients were included. Multivariate regression analyses were performed on patients with severe chest trauma (AIS ≥ 3) and patients with minor chest trauma (AIS < 3). The influence of body weight on in-hospital mortality was evaluated. Of all the patients, 70.4% were male, the median age was 52 years (IQR 36–68), the overall Injury Severity Score (ISS) was 24 points (IQR 17–29), and a median BMI of 25.1 points (IQR 23–28) was determined. In general, chest trauma was associated with prolonged ventilation, prolonged ICU treatment, and increased mortality. For overweight patients with severe chest trauma, an independent survival benefit was found (OR 0.158; p = 0.037). Overweight seems to have an impact on the mortality of severely injured patients with combined chest trauma. Potentially, a nutritive advantage or still-unknown immunological aspects in these patients affecting the intensive treatment course could be argued.
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spelling pubmed-75647602020-10-26 Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients Eckhardt, Thurid Horst, Klemens Störmann, Philipp Bläsius, Felix Hofman, Martijn Herren, Christian Kobbe, Philipp Hildebrand, Frank Andruszkow, Hagen J Clin Med Article The morbidity and mortality of severely injured patients are commonly affected by multiple factors. Especially, severe chest trauma has been shown to be a significant factor in considering outcome. Contemporaneously, weight-associated endocrinological, haematological, and metabolic deviations from the norm seem to have an impact on the posttraumatic course. Therefore, the aim of this study was to determine the influence of body weight on severely injured patients by emphasizing chest trauma. A total of 338 severely injured patients were included. Multivariate regression analyses were performed on patients with severe chest trauma (AIS ≥ 3) and patients with minor chest trauma (AIS < 3). The influence of body weight on in-hospital mortality was evaluated. Of all the patients, 70.4% were male, the median age was 52 years (IQR 36–68), the overall Injury Severity Score (ISS) was 24 points (IQR 17–29), and a median BMI of 25.1 points (IQR 23–28) was determined. In general, chest trauma was associated with prolonged ventilation, prolonged ICU treatment, and increased mortality. For overweight patients with severe chest trauma, an independent survival benefit was found (OR 0.158; p = 0.037). Overweight seems to have an impact on the mortality of severely injured patients with combined chest trauma. Potentially, a nutritive advantage or still-unknown immunological aspects in these patients affecting the intensive treatment course could be argued. MDPI 2020-08-26 /pmc/articles/PMC7564760/ /pubmed/32858822 http://dx.doi.org/10.3390/jcm9092752 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eckhardt, Thurid
Horst, Klemens
Störmann, Philipp
Bläsius, Felix
Hofman, Martijn
Herren, Christian
Kobbe, Philipp
Hildebrand, Frank
Andruszkow, Hagen
Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title_full Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title_fullStr Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title_full_unstemmed Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title_short Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients
title_sort impact of chest trauma and overweight on mortality and outcome in severely injured patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564760/
https://www.ncbi.nlm.nih.gov/pubmed/32858822
http://dx.doi.org/10.3390/jcm9092752
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