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Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired vo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564773/ https://www.ncbi.nlm.nih.gov/pubmed/32927900 http://dx.doi.org/10.3390/brainsci10090627 |
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author | Lee, Kyoung Bo Lim, Seong Hoon Park, Geun-Young Im, Sun |
author_facet | Lee, Kyoung Bo Lim, Seong Hoon Park, Geun-Young Im, Sun |
author_sort | Lee, Kyoung Bo |
collection | PubMed |
description | Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired voluntary cough. Here, we studied the effects of stroke lesions on voluntary cough using voxel-based lesion-symptom mapping (VLSM). In this retrospective cross-sectional study, the peak cough flow was measured in patients who complained of weak cough (n = 39) after supratentorial lesions. Brain lesions were visualized via magnetic resonance imaging (MRI) at the onset of stroke. These lesions were studied using VLSM. The VLSM method with non-parametric mapping revealed that lesions in the sub-gyral frontal lobe and superior longitudinal and posterior corona radiata were associated with a weak cough flow. In addition, lesions in the inferior parietal and temporal lobes and both the superior and mid-temporal gyrus were associated with a weak peak cough flow during voluntary coughing. This study identified several brain lesions underlying impaired voluntary cough. The results might be useful in predicting those at risk of poor cough function and may improve the prognosis of patients at increased risk of respiratory complications after a stroke. |
format | Online Article Text |
id | pubmed-7564773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75647732020-10-26 Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study Lee, Kyoung Bo Lim, Seong Hoon Park, Geun-Young Im, Sun Brain Sci Article Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired voluntary cough. Here, we studied the effects of stroke lesions on voluntary cough using voxel-based lesion-symptom mapping (VLSM). In this retrospective cross-sectional study, the peak cough flow was measured in patients who complained of weak cough (n = 39) after supratentorial lesions. Brain lesions were visualized via magnetic resonance imaging (MRI) at the onset of stroke. These lesions were studied using VLSM. The VLSM method with non-parametric mapping revealed that lesions in the sub-gyral frontal lobe and superior longitudinal and posterior corona radiata were associated with a weak cough flow. In addition, lesions in the inferior parietal and temporal lobes and both the superior and mid-temporal gyrus were associated with a weak peak cough flow during voluntary coughing. This study identified several brain lesions underlying impaired voluntary cough. The results might be useful in predicting those at risk of poor cough function and may improve the prognosis of patients at increased risk of respiratory complications after a stroke. MDPI 2020-09-10 /pmc/articles/PMC7564773/ /pubmed/32927900 http://dx.doi.org/10.3390/brainsci10090627 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Kyoung Bo Lim, Seong Hoon Park, Geun-Young Im, Sun Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title | Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title_full | Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title_fullStr | Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title_full_unstemmed | Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title_short | Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study |
title_sort | effect of brain lesions on voluntary cough in patients with supratentorial stroke: an observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564773/ https://www.ncbi.nlm.nih.gov/pubmed/32927900 http://dx.doi.org/10.3390/brainsci10090627 |
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