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Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies

Several societies have published recommendations for evaluating older adults with cancer in standard conditions. It is vital to assure a proper systematic patient condition evaluation, not only in the oldest (geriatric assessment) but in all adult patients. We have investigated the feasibility of a...

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Autores principales: Ramos, Fernando, González-Carmona, Paola, Porras-Guerra, María Isabel, Jiménez-Mola, Sonia, Martínez-Peláez, Ana María, Blanco-Cabielles, Agustín, Conde, Saray, Ahmadi, Abdolah, Castellanos, Marta, Cerdá, Seila, de las Heras, Natalia, Menéndez, Elisa, Escalante, Fernando, Fernández-Ferrero, Silvia, Lado, Tamara, Martínez-Robles, Violeta, Rondón, Filomeno, Padilla, Irene, Vidal, María Jesús, Villalobos, María Lavinia, Yacoubi, Saad, Idoate-Gil, Francisco Javier, Rodríguez-García, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564839/
https://www.ncbi.nlm.nih.gov/pubmed/32867114
http://dx.doi.org/10.3390/jpm10030106
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author Ramos, Fernando
González-Carmona, Paola
Porras-Guerra, María Isabel
Jiménez-Mola, Sonia
Martínez-Peláez, Ana María
Blanco-Cabielles, Agustín
Conde, Saray
Ahmadi, Abdolah
Castellanos, Marta
Cerdá, Seila
de las Heras, Natalia
Menéndez, Elisa
Escalante, Fernando
Fernández-Ferrero, Silvia
Lado, Tamara
Martínez-Robles, Violeta
Rondón, Filomeno
Padilla, Irene
Vidal, María Jesús
Villalobos, María Lavinia
Yacoubi, Saad
Idoate-Gil, Francisco Javier
Rodríguez-García, José Antonio
author_facet Ramos, Fernando
González-Carmona, Paola
Porras-Guerra, María Isabel
Jiménez-Mola, Sonia
Martínez-Peláez, Ana María
Blanco-Cabielles, Agustín
Conde, Saray
Ahmadi, Abdolah
Castellanos, Marta
Cerdá, Seila
de las Heras, Natalia
Menéndez, Elisa
Escalante, Fernando
Fernández-Ferrero, Silvia
Lado, Tamara
Martínez-Robles, Violeta
Rondón, Filomeno
Padilla, Irene
Vidal, María Jesús
Villalobos, María Lavinia
Yacoubi, Saad
Idoate-Gil, Francisco Javier
Rodríguez-García, José Antonio
author_sort Ramos, Fernando
collection PubMed
description Several societies have published recommendations for evaluating older adults with cancer in standard conditions. It is vital to assure a proper systematic patient condition evaluation, not only in the oldest (geriatric assessment) but in all adult patients. We have investigated the feasibility of a systematic evaluation of the general condition of all patients diagnosed with hematologic malignancies, and the degree of acceptance by the clinical team, in a prospective cohort of 182 consecutive adults, by using the ECOG performance status scale (ECOG, age 18 and over, 18+), Lee Index for Older Adults (LEE, 50+), Geriatric Assessment in Hematology (GAH, 65+), and the Comprehensive Geriatric Assessment (CGA, 75+). Clinical team acceptance was analyzed with a visual analogue scale, and the objective feasibility was calculated as the proportion of patients that could be finally evaluated with each tool. Acceptance was high, but the objective feasibility was progressively lower as the complexity of the different tools increased (ECOG 100%, LEE 99.4%, GAH 93.2%, and CGA 67.9%). LEE and GAH categories showed a weak concordance (Cohen’s Kappa 0.24) that was slight between LEE and CGA (Kappa 0.18). Unexpectedly, we found no significant association between the GAH and CGA categories (p = 0.16). We confirm that a systematic evaluation of all adult patients diagnosed with hematologic malignancies is feasible in daily practice by using an age-adapted approach. Direct comparisons among the different predictive tools in regard to patients’ tolerance to treatments of different intensities must be a priority research subject in the coming years.
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spelling pubmed-75648392020-10-26 Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies Ramos, Fernando González-Carmona, Paola Porras-Guerra, María Isabel Jiménez-Mola, Sonia Martínez-Peláez, Ana María Blanco-Cabielles, Agustín Conde, Saray Ahmadi, Abdolah Castellanos, Marta Cerdá, Seila de las Heras, Natalia Menéndez, Elisa Escalante, Fernando Fernández-Ferrero, Silvia Lado, Tamara Martínez-Robles, Violeta Rondón, Filomeno Padilla, Irene Vidal, María Jesús Villalobos, María Lavinia Yacoubi, Saad Idoate-Gil, Francisco Javier Rodríguez-García, José Antonio J Pers Med Article Several societies have published recommendations for evaluating older adults with cancer in standard conditions. It is vital to assure a proper systematic patient condition evaluation, not only in the oldest (geriatric assessment) but in all adult patients. We have investigated the feasibility of a systematic evaluation of the general condition of all patients diagnosed with hematologic malignancies, and the degree of acceptance by the clinical team, in a prospective cohort of 182 consecutive adults, by using the ECOG performance status scale (ECOG, age 18 and over, 18+), Lee Index for Older Adults (LEE, 50+), Geriatric Assessment in Hematology (GAH, 65+), and the Comprehensive Geriatric Assessment (CGA, 75+). Clinical team acceptance was analyzed with a visual analogue scale, and the objective feasibility was calculated as the proportion of patients that could be finally evaluated with each tool. Acceptance was high, but the objective feasibility was progressively lower as the complexity of the different tools increased (ECOG 100%, LEE 99.4%, GAH 93.2%, and CGA 67.9%). LEE and GAH categories showed a weak concordance (Cohen’s Kappa 0.24) that was slight between LEE and CGA (Kappa 0.18). Unexpectedly, we found no significant association between the GAH and CGA categories (p = 0.16). We confirm that a systematic evaluation of all adult patients diagnosed with hematologic malignancies is feasible in daily practice by using an age-adapted approach. Direct comparisons among the different predictive tools in regard to patients’ tolerance to treatments of different intensities must be a priority research subject in the coming years. MDPI 2020-08-27 /pmc/articles/PMC7564839/ /pubmed/32867114 http://dx.doi.org/10.3390/jpm10030106 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramos, Fernando
González-Carmona, Paola
Porras-Guerra, María Isabel
Jiménez-Mola, Sonia
Martínez-Peláez, Ana María
Blanco-Cabielles, Agustín
Conde, Saray
Ahmadi, Abdolah
Castellanos, Marta
Cerdá, Seila
de las Heras, Natalia
Menéndez, Elisa
Escalante, Fernando
Fernández-Ferrero, Silvia
Lado, Tamara
Martínez-Robles, Violeta
Rondón, Filomeno
Padilla, Irene
Vidal, María Jesús
Villalobos, María Lavinia
Yacoubi, Saad
Idoate-Gil, Francisco Javier
Rodríguez-García, José Antonio
Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title_full Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title_fullStr Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title_full_unstemmed Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title_short Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies
title_sort patient general condition at diagnosis: a systematic evaluation for adults diagnosed with hematologic malignancies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564839/
https://www.ncbi.nlm.nih.gov/pubmed/32867114
http://dx.doi.org/10.3390/jpm10030106
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