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HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis
Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melanoma (MM), head and neck, kidney, and urothelial can...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564884/ https://www.ncbi.nlm.nih.gov/pubmed/32854442 http://dx.doi.org/10.3390/cells9091964 |
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author | Correale, Pierpaolo Saladino, Rita Emilena Giannarelli, Diana Sergi, Andrea Mazzei, Maria Antonietta Bianco, Giovanna Giannicola, Rocco Iuliano, Eleonora Forte, Iris Maria Calandruccio, Natale Daniele Falzea, Antonia Consuelo Strangio, Alessandra Nardone, Valerio Pastina, Pierpaolo Tini, Paolo Luce, Amalia Caraglia, Michele Caracciolo, Daniele Mutti, Luciano Tassone, Pierfrancesco Pirtoli, Luigi Giordano, Antonio Tagliaferri, Pierosandro |
author_facet | Correale, Pierpaolo Saladino, Rita Emilena Giannarelli, Diana Sergi, Andrea Mazzei, Maria Antonietta Bianco, Giovanna Giannicola, Rocco Iuliano, Eleonora Forte, Iris Maria Calandruccio, Natale Daniele Falzea, Antonia Consuelo Strangio, Alessandra Nardone, Valerio Pastina, Pierpaolo Tini, Paolo Luce, Amalia Caraglia, Michele Caracciolo, Daniele Mutti, Luciano Tassone, Pierfrancesco Pirtoli, Luigi Giordano, Antonio Tagliaferri, Pierosandro |
author_sort | Correale, Pierpaolo |
collection | PubMed |
description | Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melanoma (MM), head and neck, kidney, and urothelial cancer. Monoclonal antibodies (mAbs) against either PD-1 or PD-L1 are active agents for these patients; however, their use may be complicated by unpredictable immune-related adverse events (irAEs), including immune-related pneumonitis (IRP). We carried out a retrospective multi-institutional statistical analysis to investigate clinical and biological parameters correlated with IRP rate on a cohort of 256 patients who received real-world treatment with PD-1/PD-L1 blocking mAbs. An independent radiological review board detected IRP in 29 patients. We did not find statistical IRP rate correlation with gender, tumor type, specific PD-1 or PD-L1 blocking mAbs, radiation therapy, inflammatory profile, or different irAEs. A higher IRP risk was detected only in mNSCLC patients who received metronomic chemotherapy +/− bevacizumab compared with other treatments prior PD-1/PD-L1 blockade. Moreover, we detected a strong correlation among the IRP rate and germinal expression of HLA-B*35 and DRB1*11, alleles associated to autoimmune diseases. Our findings may have relevant implications in predicting the IRP rate in mNSCLC patients receiving PD-1/PD-L1 blockade and need to be validated on a larger patient series. |
format | Online Article Text |
id | pubmed-7564884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75648842020-10-26 HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis Correale, Pierpaolo Saladino, Rita Emilena Giannarelli, Diana Sergi, Andrea Mazzei, Maria Antonietta Bianco, Giovanna Giannicola, Rocco Iuliano, Eleonora Forte, Iris Maria Calandruccio, Natale Daniele Falzea, Antonia Consuelo Strangio, Alessandra Nardone, Valerio Pastina, Pierpaolo Tini, Paolo Luce, Amalia Caraglia, Michele Caracciolo, Daniele Mutti, Luciano Tassone, Pierfrancesco Pirtoli, Luigi Giordano, Antonio Tagliaferri, Pierosandro Cells Article Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melanoma (MM), head and neck, kidney, and urothelial cancer. Monoclonal antibodies (mAbs) against either PD-1 or PD-L1 are active agents for these patients; however, their use may be complicated by unpredictable immune-related adverse events (irAEs), including immune-related pneumonitis (IRP). We carried out a retrospective multi-institutional statistical analysis to investigate clinical and biological parameters correlated with IRP rate on a cohort of 256 patients who received real-world treatment with PD-1/PD-L1 blocking mAbs. An independent radiological review board detected IRP in 29 patients. We did not find statistical IRP rate correlation with gender, tumor type, specific PD-1 or PD-L1 blocking mAbs, radiation therapy, inflammatory profile, or different irAEs. A higher IRP risk was detected only in mNSCLC patients who received metronomic chemotherapy +/− bevacizumab compared with other treatments prior PD-1/PD-L1 blockade. Moreover, we detected a strong correlation among the IRP rate and germinal expression of HLA-B*35 and DRB1*11, alleles associated to autoimmune diseases. Our findings may have relevant implications in predicting the IRP rate in mNSCLC patients receiving PD-1/PD-L1 blockade and need to be validated on a larger patient series. MDPI 2020-08-25 /pmc/articles/PMC7564884/ /pubmed/32854442 http://dx.doi.org/10.3390/cells9091964 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Correale, Pierpaolo Saladino, Rita Emilena Giannarelli, Diana Sergi, Andrea Mazzei, Maria Antonietta Bianco, Giovanna Giannicola, Rocco Iuliano, Eleonora Forte, Iris Maria Calandruccio, Natale Daniele Falzea, Antonia Consuelo Strangio, Alessandra Nardone, Valerio Pastina, Pierpaolo Tini, Paolo Luce, Amalia Caraglia, Michele Caracciolo, Daniele Mutti, Luciano Tassone, Pierfrancesco Pirtoli, Luigi Giordano, Antonio Tagliaferri, Pierosandro HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title | HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title_full | HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title_fullStr | HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title_full_unstemmed | HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title_short | HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis |
title_sort | hla expression correlates to the risk of immune checkpoint inhibitor-induced pneumonitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564884/ https://www.ncbi.nlm.nih.gov/pubmed/32854442 http://dx.doi.org/10.3390/cells9091964 |
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