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Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants

Among hematologic malignancies, the classic Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related cancer development. In this context, the use of immune-modulating agents has recently expanded the MPN therapeutic scenario. Cytokines are key...

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Autores principales: Masselli, Elena, Pozzi, Giulia, Gobbi, Giuliana, Merighi, Stefania, Gessi, Stefania, Vitale, Marco, Carubbi, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564952/
https://www.ncbi.nlm.nih.gov/pubmed/32967342
http://dx.doi.org/10.3390/cells9092136
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author Masselli, Elena
Pozzi, Giulia
Gobbi, Giuliana
Merighi, Stefania
Gessi, Stefania
Vitale, Marco
Carubbi, Cecilia
author_facet Masselli, Elena
Pozzi, Giulia
Gobbi, Giuliana
Merighi, Stefania
Gessi, Stefania
Vitale, Marco
Carubbi, Cecilia
author_sort Masselli, Elena
collection PubMed
description Among hematologic malignancies, the classic Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related cancer development. In this context, the use of immune-modulating agents has recently expanded the MPN therapeutic scenario. Cytokines are key mediators of an auto-amplifying, detrimental cross-talk between the MPN clone and the tumor microenvironment represented by immune, stromal, and endothelial cells. This review focuses on recent advances in cytokine-profiling of MPN patients, analyzing different expression patterns among the three main Philadelphia-negative (Ph-negative) MPNs, as well as correlations with disease molecular profile, phenotype, progression, and outcome. The role of the megakaryocytic clone as the main source of cytokines, particularly in myelofibrosis, is also reviewed. Finally, we report emerging intriguing evidence on the contribution of host genetic variants to the chronic pro-inflammatory state that typifies MPNs.
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spelling pubmed-75649522020-10-26 Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants Masselli, Elena Pozzi, Giulia Gobbi, Giuliana Merighi, Stefania Gessi, Stefania Vitale, Marco Carubbi, Cecilia Cells Review Among hematologic malignancies, the classic Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related cancer development. In this context, the use of immune-modulating agents has recently expanded the MPN therapeutic scenario. Cytokines are key mediators of an auto-amplifying, detrimental cross-talk between the MPN clone and the tumor microenvironment represented by immune, stromal, and endothelial cells. This review focuses on recent advances in cytokine-profiling of MPN patients, analyzing different expression patterns among the three main Philadelphia-negative (Ph-negative) MPNs, as well as correlations with disease molecular profile, phenotype, progression, and outcome. The role of the megakaryocytic clone as the main source of cytokines, particularly in myelofibrosis, is also reviewed. Finally, we report emerging intriguing evidence on the contribution of host genetic variants to the chronic pro-inflammatory state that typifies MPNs. MDPI 2020-09-21 /pmc/articles/PMC7564952/ /pubmed/32967342 http://dx.doi.org/10.3390/cells9092136 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Masselli, Elena
Pozzi, Giulia
Gobbi, Giuliana
Merighi, Stefania
Gessi, Stefania
Vitale, Marco
Carubbi, Cecilia
Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title_full Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title_fullStr Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title_full_unstemmed Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title_short Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants
title_sort cytokine profiling in myeloproliferative neoplasms: overview on phenotype correlation, outcome prediction, and role of genetic variants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564952/
https://www.ncbi.nlm.nih.gov/pubmed/32967342
http://dx.doi.org/10.3390/cells9092136
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