Cargando…
In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central ner...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565089/ https://www.ncbi.nlm.nih.gov/pubmed/32839410 http://dx.doi.org/10.3390/cells9091941 |
_version_ | 1783595860143112192 |
---|---|
author | Tournier, Benjamin B. Tsartsalis, Stergios Ceyzériat, Kelly Garibotto, Valentina Millet, Philippe |
author_facet | Tournier, Benjamin B. Tsartsalis, Stergios Ceyzériat, Kelly Garibotto, Valentina Millet, Philippe |
author_sort | Tournier, Benjamin B. |
collection | PubMed |
description | In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We focus on two pathological conditions for which neuropathological studies have shown the presence of neuroinflammation, which translates in opposite in vivo expression of TSPO. Alzheimer’s disease has been the most widely assessed with more than forty preclinical and clinical studies, showing overall that TSPO is upregulated in this condition, despite differences in the topography of this increase, its time-course and the associated cell types. In the case of schizophrenia, a reduction of TSPO has instead been observed, though the evidence remains scarce and contradictory. This review focuses on the key characteristics of TSPO as a biomarker of neuroinflammation in vivo, namely, on the cellular origin of the variations in its expression, on its possible biological/pathological role and on its variations across disease phases. |
format | Online Article Text |
id | pubmed-7565089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75650892020-10-26 In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease Tournier, Benjamin B. Tsartsalis, Stergios Ceyzériat, Kelly Garibotto, Valentina Millet, Philippe Cells Review In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We focus on two pathological conditions for which neuropathological studies have shown the presence of neuroinflammation, which translates in opposite in vivo expression of TSPO. Alzheimer’s disease has been the most widely assessed with more than forty preclinical and clinical studies, showing overall that TSPO is upregulated in this condition, despite differences in the topography of this increase, its time-course and the associated cell types. In the case of schizophrenia, a reduction of TSPO has instead been observed, though the evidence remains scarce and contradictory. This review focuses on the key characteristics of TSPO as a biomarker of neuroinflammation in vivo, namely, on the cellular origin of the variations in its expression, on its possible biological/pathological role and on its variations across disease phases. MDPI 2020-08-21 /pmc/articles/PMC7565089/ /pubmed/32839410 http://dx.doi.org/10.3390/cells9091941 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tournier, Benjamin B. Tsartsalis, Stergios Ceyzériat, Kelly Garibotto, Valentina Millet, Philippe In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title | In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title_full | In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title_fullStr | In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title_full_unstemmed | In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title_short | In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease |
title_sort | in vivo tspo signal and neuroinflammation in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565089/ https://www.ncbi.nlm.nih.gov/pubmed/32839410 http://dx.doi.org/10.3390/cells9091941 |
work_keys_str_mv | AT tournierbenjaminb invivotsposignalandneuroinflammationinalzheimersdisease AT tsartsalisstergios invivotsposignalandneuroinflammationinalzheimersdisease AT ceyzeriatkelly invivotsposignalandneuroinflammationinalzheimersdisease AT garibottovalentina invivotsposignalandneuroinflammationinalzheimersdisease AT milletphilippe invivotsposignalandneuroinflammationinalzheimersdisease |