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Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines
Pestivirus A or bovine viral diarrhoea virus (BVDV) type 1 is responsible for cosmopolitan diseases affecting cattle and other ruminants, presenting a wide range of clinical manifestations, with relevant impact on zootechnic production. The objective of the present study was to verify whether animal...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565157/ https://www.ncbi.nlm.nih.gov/pubmed/32664468 http://dx.doi.org/10.3390/vaccines8030374 |
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author | Sozzi, Enrica Righi, Cecilia Boldini, Massimo Bazzucchi, Moira Pezzoni, Giulia Gradassi, Matteo Petrini, Stefano Lelli, Davide Ventura, Giordano Pierini, Ilaria Moreno, Ana Brocchi, Emiliana Lavazza, Antonio De Mia, Gian Mario |
author_facet | Sozzi, Enrica Righi, Cecilia Boldini, Massimo Bazzucchi, Moira Pezzoni, Giulia Gradassi, Matteo Petrini, Stefano Lelli, Davide Ventura, Giordano Pierini, Ilaria Moreno, Ana Brocchi, Emiliana Lavazza, Antonio De Mia, Gian Mario |
author_sort | Sozzi, Enrica |
collection | PubMed |
description | Pestivirus A or bovine viral diarrhoea virus (BVDV) type 1 is responsible for cosmopolitan diseases affecting cattle and other ruminants, presenting a wide range of clinical manifestations, with relevant impact on zootechnic production. The objective of the present study was to verify whether animals immunised with four commercial vaccines also developed a protective humoral immunity against other viral subgenotypes than those contained in each vaccine. Four groups of 25 bovines each were formed and vaccinated according to the manufacturer’s instructions of the commercial vaccines. On sera collected 28 days after the last vaccination, virus neutralisation tests (VNT) were performed using homologous and heterologous viruses and enzyme-linked immunosorbent assay (ELISA) methods. Finally, the VNT results were comparatively evaluated through a statistical analysis. Serological results highlighted that, although with a different degree of efficiency, the four vaccines resulted in not developing a solid antibody-mediated cross-immunity against all the strains used. |
format | Online Article Text |
id | pubmed-7565157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75651572020-10-26 Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines Sozzi, Enrica Righi, Cecilia Boldini, Massimo Bazzucchi, Moira Pezzoni, Giulia Gradassi, Matteo Petrini, Stefano Lelli, Davide Ventura, Giordano Pierini, Ilaria Moreno, Ana Brocchi, Emiliana Lavazza, Antonio De Mia, Gian Mario Vaccines (Basel) Article Pestivirus A or bovine viral diarrhoea virus (BVDV) type 1 is responsible for cosmopolitan diseases affecting cattle and other ruminants, presenting a wide range of clinical manifestations, with relevant impact on zootechnic production. The objective of the present study was to verify whether animals immunised with four commercial vaccines also developed a protective humoral immunity against other viral subgenotypes than those contained in each vaccine. Four groups of 25 bovines each were formed and vaccinated according to the manufacturer’s instructions of the commercial vaccines. On sera collected 28 days after the last vaccination, virus neutralisation tests (VNT) were performed using homologous and heterologous viruses and enzyme-linked immunosorbent assay (ELISA) methods. Finally, the VNT results were comparatively evaluated through a statistical analysis. Serological results highlighted that, although with a different degree of efficiency, the four vaccines resulted in not developing a solid antibody-mediated cross-immunity against all the strains used. MDPI 2020-07-11 /pmc/articles/PMC7565157/ /pubmed/32664468 http://dx.doi.org/10.3390/vaccines8030374 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sozzi, Enrica Righi, Cecilia Boldini, Massimo Bazzucchi, Moira Pezzoni, Giulia Gradassi, Matteo Petrini, Stefano Lelli, Davide Ventura, Giordano Pierini, Ilaria Moreno, Ana Brocchi, Emiliana Lavazza, Antonio De Mia, Gian Mario Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title | Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title_full | Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title_fullStr | Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title_full_unstemmed | Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title_short | Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines |
title_sort | cross-reactivity antibody response after vaccination with modified live and killed bovine viral diarrhoea virus (bvd) vaccines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565157/ https://www.ncbi.nlm.nih.gov/pubmed/32664468 http://dx.doi.org/10.3390/vaccines8030374 |
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