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Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?

We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by imm...

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Detalles Bibliográficos
Autores principales: Klitz, William, Niklasson, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565261/
https://www.ncbi.nlm.nih.gov/pubmed/32927606
http://dx.doi.org/10.3390/microorganisms8091382
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author Klitz, William
Niklasson, Bo
author_facet Klitz, William
Niklasson, Bo
author_sort Klitz, William
collection PubMed
description We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by immunohistochemistry was seen in islets of Langerhans in diabetic wild bank voles. LV antigen has also been found in islets of Langerhans in a patient with recent onset of T1D and in the commonly used Bio Breeding (BB) T1D rat model. We discuss the possibility of T1D and type 2 diabetes (T2D) as parts of a single disease entity. Antiviral compounds directed against picornavirus have been found to be an effective treatment of diabetes in BB rats. We propose using the same currently available antiviral compounds in clinical trials in humans. Antiviral treatment would have the potential to be both proof of concept for involvement of a picornavirus in diabetes pathogenesis and also present a first-generation therapy.
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spelling pubmed-75652612020-10-26 Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? Klitz, William Niklasson, Bo Microorganisms Review We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by immunohistochemistry was seen in islets of Langerhans in diabetic wild bank voles. LV antigen has also been found in islets of Langerhans in a patient with recent onset of T1D and in the commonly used Bio Breeding (BB) T1D rat model. We discuss the possibility of T1D and type 2 diabetes (T2D) as parts of a single disease entity. Antiviral compounds directed against picornavirus have been found to be an effective treatment of diabetes in BB rats. We propose using the same currently available antiviral compounds in clinical trials in humans. Antiviral treatment would have the potential to be both proof of concept for involvement of a picornavirus in diabetes pathogenesis and also present a first-generation therapy. MDPI 2020-09-10 /pmc/articles/PMC7565261/ /pubmed/32927606 http://dx.doi.org/10.3390/microorganisms8091382 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Klitz, William
Niklasson, Bo
Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title_full Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title_fullStr Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title_full_unstemmed Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title_short Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
title_sort extending the enterovirus lead: could a related picornavirus be responsible for diabetes in humans?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565261/
https://www.ncbi.nlm.nih.gov/pubmed/32927606
http://dx.doi.org/10.3390/microorganisms8091382
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