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Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?
We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by imm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565261/ https://www.ncbi.nlm.nih.gov/pubmed/32927606 http://dx.doi.org/10.3390/microorganisms8091382 |
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author | Klitz, William Niklasson, Bo |
author_facet | Klitz, William Niklasson, Bo |
author_sort | Klitz, William |
collection | PubMed |
description | We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by immunohistochemistry was seen in islets of Langerhans in diabetic wild bank voles. LV antigen has also been found in islets of Langerhans in a patient with recent onset of T1D and in the commonly used Bio Breeding (BB) T1D rat model. We discuss the possibility of T1D and type 2 diabetes (T2D) as parts of a single disease entity. Antiviral compounds directed against picornavirus have been found to be an effective treatment of diabetes in BB rats. We propose using the same currently available antiviral compounds in clinical trials in humans. Antiviral treatment would have the potential to be both proof of concept for involvement of a picornavirus in diabetes pathogenesis and also present a first-generation therapy. |
format | Online Article Text |
id | pubmed-7565261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75652612020-10-26 Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? Klitz, William Niklasson, Bo Microorganisms Review We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by immunohistochemistry was seen in islets of Langerhans in diabetic wild bank voles. LV antigen has also been found in islets of Langerhans in a patient with recent onset of T1D and in the commonly used Bio Breeding (BB) T1D rat model. We discuss the possibility of T1D and type 2 diabetes (T2D) as parts of a single disease entity. Antiviral compounds directed against picornavirus have been found to be an effective treatment of diabetes in BB rats. We propose using the same currently available antiviral compounds in clinical trials in humans. Antiviral treatment would have the potential to be both proof of concept for involvement of a picornavirus in diabetes pathogenesis and also present a first-generation therapy. MDPI 2020-09-10 /pmc/articles/PMC7565261/ /pubmed/32927606 http://dx.doi.org/10.3390/microorganisms8091382 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Klitz, William Niklasson, Bo Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title | Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title_full | Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title_fullStr | Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title_full_unstemmed | Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title_short | Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans? |
title_sort | extending the enterovirus lead: could a related picornavirus be responsible for diabetes in humans? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565261/ https://www.ncbi.nlm.nih.gov/pubmed/32927606 http://dx.doi.org/10.3390/microorganisms8091382 |
work_keys_str_mv | AT klitzwilliam extendingtheenterovirusleadcouldarelatedpicornavirusberesponsiblefordiabetesinhumans AT niklassonbo extendingtheenterovirusleadcouldarelatedpicornavirusberesponsiblefordiabetesinhumans |