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Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

(1) Background: Lymphoepithelial carcinoma of the hypopharynx and larynx is a rare tumor with fewer than 50 cases in the published literature. We present a literature review to discuss the clinical findings, viral or genetic associations, diagnostic challenges, histopathological findings and therape...

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Autores principales: Faisal, Muhammad, Hartenbach, Sabrina, Schratter, Annemarie, Köstler, Wolfgang J., Kaufmann, Hannes, Seemann, Rudolf, Lill, Claudia, Hamzavi, Sasan, Wutzl, Arno, Erovic, Boban M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565469/
https://www.ncbi.nlm.nih.gov/pubmed/32867094
http://dx.doi.org/10.3390/cancers12092431
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author Faisal, Muhammad
Hartenbach, Sabrina
Schratter, Annemarie
Köstler, Wolfgang J.
Kaufmann, Hannes
Seemann, Rudolf
Lill, Claudia
Hamzavi, Sasan
Wutzl, Arno
Erovic, Boban M.
author_facet Faisal, Muhammad
Hartenbach, Sabrina
Schratter, Annemarie
Köstler, Wolfgang J.
Kaufmann, Hannes
Seemann, Rudolf
Lill, Claudia
Hamzavi, Sasan
Wutzl, Arno
Erovic, Boban M.
author_sort Faisal, Muhammad
collection PubMed
description (1) Background: Lymphoepithelial carcinoma of the hypopharynx and larynx is a rare tumor with fewer than 50 cases in the published literature. We present a literature review to discuss the clinical findings, viral or genetic associations, diagnostic challenges, histopathological findings and therapeutic aspects of the disease. (2) Methods: A comprehensive literature review was performed through MEDLINE/PubMed from 1968 to 2018. We identified 21 studies comprising 46 patients. Data on all the clinicopathological features, diagnostic modalities, treatment options and viral or genetic etiology were extracted and analyzed using SPSS. (3) Results: The mean age of presentation was 64 years (range 40–82 years) and mostly involved males. The supraglottis and pyriform sinus were the most commonly involved sub-sites, with surgery as the preferred treatment modality. The presence of the Epstein–Barr virus possibly directs a viral etiology. The incidence of cervical and distant metastasis was 54% and 21%, respectively. The median survival time was 30 months. (4) Conclusions: Lymphoepithelial carcinoma of the hypopharynx is an aggressive tumor with a strong predilection for regional and distant metastasis. Surgery, in combination with adjuvant therapy, provides promising results. Immunohistochemistry helps in differentiating LEC from other pathologies.
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spelling pubmed-75654692020-10-26 Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity Faisal, Muhammad Hartenbach, Sabrina Schratter, Annemarie Köstler, Wolfgang J. Kaufmann, Hannes Seemann, Rudolf Lill, Claudia Hamzavi, Sasan Wutzl, Arno Erovic, Boban M. Cancers (Basel) Review (1) Background: Lymphoepithelial carcinoma of the hypopharynx and larynx is a rare tumor with fewer than 50 cases in the published literature. We present a literature review to discuss the clinical findings, viral or genetic associations, diagnostic challenges, histopathological findings and therapeutic aspects of the disease. (2) Methods: A comprehensive literature review was performed through MEDLINE/PubMed from 1968 to 2018. We identified 21 studies comprising 46 patients. Data on all the clinicopathological features, diagnostic modalities, treatment options and viral or genetic etiology were extracted and analyzed using SPSS. (3) Results: The mean age of presentation was 64 years (range 40–82 years) and mostly involved males. The supraglottis and pyriform sinus were the most commonly involved sub-sites, with surgery as the preferred treatment modality. The presence of the Epstein–Barr virus possibly directs a viral etiology. The incidence of cervical and distant metastasis was 54% and 21%, respectively. The median survival time was 30 months. (4) Conclusions: Lymphoepithelial carcinoma of the hypopharynx is an aggressive tumor with a strong predilection for regional and distant metastasis. Surgery, in combination with adjuvant therapy, provides promising results. Immunohistochemistry helps in differentiating LEC from other pathologies. MDPI 2020-08-27 /pmc/articles/PMC7565469/ /pubmed/32867094 http://dx.doi.org/10.3390/cancers12092431 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Faisal, Muhammad
Hartenbach, Sabrina
Schratter, Annemarie
Köstler, Wolfgang J.
Kaufmann, Hannes
Seemann, Rudolf
Lill, Claudia
Hamzavi, Sasan
Wutzl, Arno
Erovic, Boban M.
Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title_full Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title_fullStr Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title_full_unstemmed Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title_short Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
title_sort lymphoepithelial carcinoma of larynx and hypopharynx: a rare clinicopathological entity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565469/
https://www.ncbi.nlm.nih.gov/pubmed/32867094
http://dx.doi.org/10.3390/cancers12092431
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