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Japan’s Ongoing Crisis on HPV Vaccination

The Japanese government suspended proactive recommendations for the HPV vaccine in June 2013. The suspension is now in its seventh year, despite all the data pointing to the safety of the HPV vaccine. We reported a high vaccine effectiveness in the group of women vaccinated before their first interc...

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Autores principales: Sekine, Masayuki, Kudo, Risa, Yamaguchi, Manako, J. B. Hanley, Sharon, Hara, Megumi, Adachi, Sosuke, Ueda, Yutaka, Miyagi, Etsuko, Ikeda, Sayaka, Yagi, Asami, Enomoto, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565470/
https://www.ncbi.nlm.nih.gov/pubmed/32640691
http://dx.doi.org/10.3390/vaccines8030362
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author Sekine, Masayuki
Kudo, Risa
Yamaguchi, Manako
J. B. Hanley, Sharon
Hara, Megumi
Adachi, Sosuke
Ueda, Yutaka
Miyagi, Etsuko
Ikeda, Sayaka
Yagi, Asami
Enomoto, Takayuki
author_facet Sekine, Masayuki
Kudo, Risa
Yamaguchi, Manako
J. B. Hanley, Sharon
Hara, Megumi
Adachi, Sosuke
Ueda, Yutaka
Miyagi, Etsuko
Ikeda, Sayaka
Yagi, Asami
Enomoto, Takayuki
author_sort Sekine, Masayuki
collection PubMed
description The Japanese government suspended proactive recommendations for the HPV vaccine in June 2013. The suspension is now in its seventh year, despite all the data pointing to the safety of the HPV vaccine. We reported a high vaccine effectiveness in the group of women vaccinated before their first intercourse (93.9%). The prevalence of cross-protected types of HPV 31/45/52 was also lower in the vaccinated group, and the vaccine effectiveness was 67.7%. Furthermore, prevalence of HPV16, 31 and 52 infection rates in the vaccinated group were obviously lower than that in the unvaccinated group, and no one had HPV18 or 45 infection in the vaccinated group. The addition of a cross-protective effect toward HPV types 31/45/52 to HPV types 16/18, which is the direct target of the bivalent HPV vaccine, may possibly prevent around 82% of invasive cervical cancer cases in Japan. With regard to the preventive effect of histological abnormalities, we also reported significant reduction in incidence of cervical intraepithelial neoplasia (CIN)3 or worse. Thus, the efficacy of the vaccine has been demonstrated for precancerous disease, and the diverse symptoms after HPV vaccination are likely functional somatic. For the future of Japanese girls, there is a need to resume the proactive recommendation of HPV vaccination and for immediate action to be taken by the Japanese government.
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spelling pubmed-75654702020-10-26 Japan’s Ongoing Crisis on HPV Vaccination Sekine, Masayuki Kudo, Risa Yamaguchi, Manako J. B. Hanley, Sharon Hara, Megumi Adachi, Sosuke Ueda, Yutaka Miyagi, Etsuko Ikeda, Sayaka Yagi, Asami Enomoto, Takayuki Vaccines (Basel) Review The Japanese government suspended proactive recommendations for the HPV vaccine in June 2013. The suspension is now in its seventh year, despite all the data pointing to the safety of the HPV vaccine. We reported a high vaccine effectiveness in the group of women vaccinated before their first intercourse (93.9%). The prevalence of cross-protected types of HPV 31/45/52 was also lower in the vaccinated group, and the vaccine effectiveness was 67.7%. Furthermore, prevalence of HPV16, 31 and 52 infection rates in the vaccinated group were obviously lower than that in the unvaccinated group, and no one had HPV18 or 45 infection in the vaccinated group. The addition of a cross-protective effect toward HPV types 31/45/52 to HPV types 16/18, which is the direct target of the bivalent HPV vaccine, may possibly prevent around 82% of invasive cervical cancer cases in Japan. With regard to the preventive effect of histological abnormalities, we also reported significant reduction in incidence of cervical intraepithelial neoplasia (CIN)3 or worse. Thus, the efficacy of the vaccine has been demonstrated for precancerous disease, and the diverse symptoms after HPV vaccination are likely functional somatic. For the future of Japanese girls, there is a need to resume the proactive recommendation of HPV vaccination and for immediate action to be taken by the Japanese government. MDPI 2020-07-06 /pmc/articles/PMC7565470/ /pubmed/32640691 http://dx.doi.org/10.3390/vaccines8030362 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sekine, Masayuki
Kudo, Risa
Yamaguchi, Manako
J. B. Hanley, Sharon
Hara, Megumi
Adachi, Sosuke
Ueda, Yutaka
Miyagi, Etsuko
Ikeda, Sayaka
Yagi, Asami
Enomoto, Takayuki
Japan’s Ongoing Crisis on HPV Vaccination
title Japan’s Ongoing Crisis on HPV Vaccination
title_full Japan’s Ongoing Crisis on HPV Vaccination
title_fullStr Japan’s Ongoing Crisis on HPV Vaccination
title_full_unstemmed Japan’s Ongoing Crisis on HPV Vaccination
title_short Japan’s Ongoing Crisis on HPV Vaccination
title_sort japan’s ongoing crisis on hpv vaccination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565470/
https://www.ncbi.nlm.nih.gov/pubmed/32640691
http://dx.doi.org/10.3390/vaccines8030362
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