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Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors

Cancer cells generate large quantities of cytoplasmic protons as byproducts of aberrantly activated aerobic glycolysis and lactate fermentation. To avoid potentially detrimental acidification of the intracellular milieu, cancer cells activate multiple acid-removal pathways that promote cytosolic alk...

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Detalles Bibliográficos
Autores principales:	Chen, Ran, Jäättelä, Marja, Liu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565471/ https://www.ncbi.nlm.nih.gov/pubmed/32867178 http://dx.doi.org/10.3390/cancers12092437

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